Translational Therapeutics
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Open Access
Featured
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Genetics and Genomics
| Open AccessArsenic-related DNA copy-number alterations in lung squamous cell carcinomas
- V D Martinez
- , T P H Buys
- & L Gil
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Epidemiology
| Open AccessIncreased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations
- G S Dite
- , A S Whittemore
- & J L Hopper
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Translational Therapeutics
| Open AccessPhase I and pharmacological study of the broad-spectrum tyrosine kinase inhibitor JNJ-26483327 in patients with advanced solid tumours
- I R H M Konings
- , M J A de Jonge
- & F A L M Eskens
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Clinical Study
| Open AccessSafety and efficacy of the combination of erlotinib and sirolimus for the treatment of metastatic renal cell carcinoma after failure of sunitinib or sorafenib
- T W Flaig
- , L J Costa
- & H Drabkin
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Clinical Study
| Open AccessLoss of tumoral expression of soluble IL-6 receptor is associated with disease progression in colorectal cancer
- Y Okugawa
- , C Miki
- & M Kusunoki
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Genetics and Genomics
| Open AccessCarcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
- K Almstrup
- , J E Nielsen
- & E Rajpert-De Meyts
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Molecular Diagnostics
| Open AccessOsteopontin is a marker for cancer aggressiveness and patient survival
- G F Weber
- , G S Lett
- & N C Haubein
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Clinical Study
| Open AccessComparison of Hybrid capture 2 testing at different thresholds with cytology as primary cervical screening test
- D C Rijkaart
- , V M H Coupe
- & C J L M Meijer
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Clinical Study
| Open AccessA randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
- T-S Yang
- , S-N Lu
- & L-T Chen
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Clinical Study
| Open AccessA phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer
- J-F Rossi
- , S Négrier
- & B Berns
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Molecular Diagnostics
| Open AccessCo-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression
- J Hao
- , H Chen
- & Y Li
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Genetics and Genomics
| Open AccessProstate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis
- S M Edwards
- , D G R Evans
- & R A Eeles
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Translational Therapeutics
| Open AccessEnzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules
- A Körner
- , G Mudduluru
- & H Allgayer
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Translational Therapeutics
| Open AccessCombination of temozolomide with immunocytokine F16–IL2 for the treatment of glioblastoma
- M Pedretti
- , C Verpelli
- & L Bello
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Translational Therapeutics
| Open AccessMGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome
- J C Hassel
- , A Sucker
- & D Schadendorf
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Epidemiology
| Open AccessProlactin serum levels and breast cancer: relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case–control study from Poland
- J M Faupel-Badger
- , M E Sherman
- & J D Figueroa
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Molecular Diagnostics
| Open AccessTumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation
- N Hiraoka
- , Y Ino
- & Y Kanai
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Clinical Study
| Open AccessPhase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent
- J D Lickliter
- , A B Francesconi
- & P A Vasey
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Translational Therapeutics
| Open AccessSelective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells
- A Strillacci
- , C Griffoni
- & E Spisni
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Molecular Diagnostics
| Open AccessSV40 associated miRNAs are not detectable in mesotheliomas
- G V Gee
- , M L Stanifer
- & K T Kelsey
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Translational Therapeutics
| Open AccessA phase I, dose-finding study of sunitinib in combination with irinotecan in patients with advanced solid tumours
- E Boven
- , C Massard
- & J C Soria
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Molecular Diagnostics
| Open AccessInactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastases
- Y Teng
- , M Q Ren
- & J K Cowell
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Translational Therapeutics
| Open AccessActivity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma
- A Santoro
- , T Pressiani
- & C Bordignon
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Molecular Diagnostics
| Open AccessBreast cancer patients’ clinical outcome measures are associated with Src kinase family member expression
- B Elsberger
- , R Fullerton
- & J Edwards
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Molecular Diagnostics
| Open AccessNOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
- N Tobar
- , J Guerrero
- & J Martínez
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Short Communication
| Open AccessIn situ quantification of HER2–protein tyrosine kinase 6 (PTK6) protein–protein complexes in paraffin sections from breast cancer tissues
- M Aubele
- , M Spears
- & J M S Bartlett
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Clinical Study
| Open AccessThe impact of CYP2D6-predicted phenotype on tamoxifen treatment outcome in patients with metastatic breast cancer
- L A Lammers
- , R H J Mathijssen
- & R H N van Schaik
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Epidemiology
| Open AccessSex-specific exposure prevalence of established risk factors for oesophageal adenocarcinoma
- M Rutegård
- , H Nordenstedt
- & P Lagergren
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Molecular Diagnostics
| Open AccessmiR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC)
- N Kikkawa
- , T Hanazawa
- & N Seki
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Translational Therapeutics
| Open AccessMolecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy
- S Glaysher
- , F G Gabriel
- & I A Cree
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Translational Therapeutics
| Open AccessDual inhibition of EGFR and mTOR pathways in small cell lung cancer
- K Schmid
- , Z Bago-Horvath
- & W Sieghart
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Molecular Diagnostics
| Open AccessWhole blood-derived miRNA profiles as potential new tools for ovarian cancer screening
- S F M Häusler
- , A Keller
- & J Wischhusen
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Letter to the Editor
| Open AccessNon-responders to topical Imiquimod followed by vaccination therapy in VIN patients may be due to the level of IL10
- X S Liu
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Molecular Diagnostics
| Open AccessANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
- C Ayoub
- , C Wasylyk
- & B Wasylyk
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Molecular Diagnostics
| Open AccessActivation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands
- B Lujan
- , S Hakim
- & L Alos
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Clinical Study
| Open AccessA retrospective analysis of clinical outcome of patients with chemo-refractory metastatic breast cancer treated in a single institution phase I unit
- A T Brunetto
- , D Sarker
- & C Swanton
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Translational Therapeutics
| Open AccessIntegrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer
- I Garrido-Laguna
- , A C Tan
- & M Hidalgo
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Translational Therapeutics
| Open AccessTP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy
- S Y Lee
- , S K Luk
- & Y M B Yung
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Translational Therapeutics
| Open AccessZoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma
- J D Veltman
- , M E H Lambers
- & J G J V Aerts
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Molecular Diagnostics
| Open AccessTargeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody–drug conjugate SGN-75
- M C Ryan
- , H Kostner
- & L M Smith
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Molecular Diagnostics
| Open AccessIdentification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer
- N Leffers
- , R S N Fehrmann
- & A G J van der Zee
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Molecular Diagnostics
| Open AccessIntegrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype
- I Van der Auwera
- , R Limame
- & S J Van Laere
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Letter to the Editor
| Open Access18S is an appropriate housekeeping gene for in vitro hypoxia experiments
- A Nagelkerke
- , H Mujcic
- & P N Span
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Letter to the Editor
| Open AccessReply: 18S is an appropriate housekeeping gene for in vitro hypoxia experiments
- J Caradec
- , N Sirab
- & S Loric
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Letter to the Editor
| Open AccessDetermining the anti-coagulant-independent anti-cancer effects of heparin
- V Solari
- , E C Jesudason
- & E A Yates
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Genetics and Genomics
| Open AccessAssociation studies on 11 published colorectal cancer risk loci
- S von Holst
- , S Picelli
- & A Lindblom
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Short Communication
| Open AccessDifferential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China
- K-M Lee
- , R S Chapman
- & Q Lan
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Translational Therapeutics
| Open AccessQuercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients
- M Russo
- , C Spagnuolo
- & G-L Russo
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