Bacterial toxins articles within Nature

Featured

  • Article |

    Retron-Sen2 of Salmonella Typhimurium encodes a toxin and a reverse transcriptase, which, together with the Sen2 multi-copy single-stranded DNA synthesized by the reverse transcriptase make up a tripartite toxin–antitoxin system that functions in anti-phage defence.

    • Jacob Bobonis
    • , Karin Mitosch
    •  & Athanasios Typas

  • Article |

    In patients with alcoholic hepatitis, cytolysin-positive Enterococcus faecalis strains are correlated with liver disease severity and increased mortality, and in mouse models these strains can be specifically targeted by bacteriophages.

    • Yi Duan
    • , Cristina Llorente
    •  & Bernd Schnabl

  • Article |

    A Staphylococcus aureus leukotoxin targets cells expressing the chemokine receptor CCR5, a mechanism for the specificity of leukotoxins towards different immune cells.

    • Francis Alonzo III
    • , Lina Kozhaya
    •  & Victor J. Torres

  • Article |

    The streptococcal M1 protein can cause vascular leakage and tissue injury and these pathologies are dependent on its interaction with host fibrinogen and subsequent activation of neutrophils. This study presents the structural basis for this process.

    • Pauline Macheboeuf
    • , Cosmo Buffalo
    •  & Partho Ghosh

  • Letter |

    During infection, Bacillus anthracis secretes two potent toxins called lethal factor and oedema factor. Using Drosophila melanogaster as a model system, these authors show that these toxins interact with the Rab11/Sec15 exocyst, which is involved in endocytic recycling. This interaction may explain vascular leakage during infection.

    • Annabel Guichard
    • , Shauna M. McGillivray
    •  & Ethan Bier

  • News & Views |

    The bacterium Clostridium difficile can cause life-threatening human disease. The question is which of the organism's two toxins is the more crucial to its pathogenicity. The answer is one or the other, or both. See Letter p.711

    • Jimmy D. Ballard

  • Letter |

    Clostridium difficile, an important nosocomial pathogen, produces two toxins. Studies with purified toxins have indicated that only toxin A is important for pathogenesis, but recently it has been suggested that toxin B causes the majority of the disease symptoms in the context of a bacterial infection. These authors demonstrate that both toxins are important for disease and will need to be considered for diagnosis and treatment.

    • Sarah A. Kuehne
    • , Stephen T. Cartman
    •  & Nigel P. Minton

Browse broader subjects

Browse Bacterial toxins across other nature.com journals