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Volume 13 Issue 11, November 2006

Work from de la Mata and Kornblihtt suggests that the C-terminal domain (CTD) of RNA polymerase II recruits the splicing repressor SRp20, thus influencing alternative splicing. Since the CTD is an elongated and flexible structure tagged by phosphate groups, the snake-like and flagged creature depicted in "Drago" by Xul Solar here represents this domain, and its interactive nature. Foundation Pan Klub-Museo Xul Solar reserved rights. pp 973-980, News and Views p 952

Volume 13 Issue 11

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News & Views

  • Recent additions to the helicase family include motor proteins that do not actually unwind DNA, but rather translocate it. By sensing short polar sequences that orient the bacterial chromosome, the FtsK helicase translocates DNA so as to align the termini of replicated chromosomes with each other, facilitating the late stages of chromosome segregation.

    • Terence R Strick
    • Audrey Quessada-Vial
    News & Views

  • Crystal structures of T4 RNA ligase 2 trapped at different stages of a multistep reaction show how one enzyme active site juggles three phosphoryl transfer reactions to join two RNA strands. The structures also show how the ligase enzyme selectively recognizes the sugar pucker of ribose to achieve catalytic specificity toward RNA-containing substrates.

    • John M Pascal
    • Tom Ellenberger
    News & Views

  • The DEAD-box ATPase Ded1 unwinds duplex RNA with a single-stranded overhang; however, Ded1 requires the overhang not for translocation but rather for loading onto the duplex. This surprising finding expands the mechanistic repertoire for the ubiquitous DExD/H-box family.

    • Rabiah M Mayas
    • Jonathan P Staley
    News & Views
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