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Volume 13 Issue 10, October 2006

The Fucini and Vila-Sanjurjo groups present a structure/function analysis of the antibiotic kasugamycin. Shown are lanterns at the Kasuga shrine in Nara, Japan. The Streptomyces strain from which kasugamycin was isolated was found near here. Image by Fabrizio Savoca. Please see pp 871-878 and 879-886, News and Views p 858

Volume 13 Issue 10

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News & Views

  • Many translation initiation inhibitors block transfer RNA binding or placement in the ribosome. Structures of kasugamycin bound to the bacterial ribosome now indicate that it instead blocks proper mRNA placement.

    • Alexander Mankin
    News & Views

  • Eukaryotic transcriptomes are considerably larger than estimated from simple gene counts. However, much of this 'excess' RNA is immediately cleared from cells. Two recent studies reveal that so-called cryptic unstable transcripts constitutively transcribed from the yeast genome are rapidly eliminated in a process that couples transcription termination to RNA degradation.

    • Søren Lykke-Andersen
    • Torben Heick Jensen
    News & Views

  • The structure of the ligand-binding domains of Vibrio harveyi LuxPQ bound to Autoinducer-2 reveals a dramatic asymmetry in quaternary structure induced by ligand binding. Structures of receptor-sensing domains in both occupied and unoccupied states provide a foundation for postulating mechanisms of transmembrane signaling.

    • Ann M Stock
    News & Views
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