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A combined structural and biochemical analysis of an essential stress protein in Escherichia coli provides the first detailed insights into a bacterial translation mechanism designed to cope with cold shock conditions.
Recent characterization of two distinct signals leading to IRF-3 activation in response to double-stranded RNA recognition by Toll-like receptor 3 provides new mechanistic information on the regulatory events that link the detection of viral invasion by the cell with the development of the antiviral response.
Retrovirus particles contain a dimeric form of their genomic RNA. A recent study suggests a mechanism that might underlie the selective incorporation of dimeric RNAs into assembling virus particles.
A new report provides evidence that the TFIIB-RNAPII interaction depends on the presence of additional factors and highlights the importance of structural characterization of the entire preinitiation complex.