Recent characterization of two distinct signals leading to IRF-3 activation in response to double-stranded RNA recognition by Toll-like receptor 3 provides new mechanistic information on the regulatory events that link the detection of viral invasion by the cell with the development of the antiviral response.
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Hiscott, J. Another detour on the Toll road to the interferon antiviral response. Nat Struct Mol Biol 11, 1028–1030 (2004). https://doi.org/10.1038/nsmb1104-1028
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DOI: https://doi.org/10.1038/nsmb1104-1028
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