Regulation of Cas7-11 by TPR-CHAT

Regulation of Cas7-11 by TPR-CHAT

The CRISPR-guided nuclease Cas7-11 forms a bird-like Craspase complex with the regulatory protease TPR-CHAT.

  • Babatunde Ekundayo
  • Davide Torre
  • Dongchun Ni
Brief Communication


  • The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch." Their research identified transient receptor potential (TRP) and PIEZO ion channels as the proteins that sense these ubiquitous stimuli. To celebrate the award Nature Portfolio presents a Collection of articles on the topic.

  • Genome editing has great potential to change how we model, understand, and treat diseases. The Somatic Cell Genome Editing Consortium brings together investigators from 33 institutions to accelerate the development of editing tools, animal models, delivery approaches and therapeutic applications of genome editing.

Nature Structural & Molecular Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • The authors demonstrate that cells that are deficient in H3K9 trimethylation display more compact mitotic chromosomes decorated with aberrantly high H3S10 phosphorylation and H3K27 trimethylation. By quantitative proteomics, they show that H3K9 trimethylation is essential for mitotic bookmarking by Esrrb and thus for the maintenance of epigenetic memory during cell division.

    • Dounia Djeghloul
    • Andrew Dimond
    • Amanda G. Fisher
    Article Open Access
  • The authors perform a computational analysis of mutagenesis at non-B DNA structures formed by repetitive sequences. Having removed confounding factors, they present a landscape of mutagenesis different than previously thought, in which mechanisms such as the formation of abnormal secondary structures, polymerase slippage and occasional takeover by error-prone polymerases play an important role within, but not surrounding, the motifs.

    • R. J. McGinty
    • S. R. Sunyaev
  • The authors show that the assembly of the meiotic chromosome axis in worms depends on activation of the master DNA-damage response kinase ATM, which leads to destabilization of the cohesin-unloader WAPL. Similar ATM-dependent WAPL inhibition also occurs in cohesin-rich genomic regions upon DNA-damage induction.

    • Zhouliang Yu
    • Hyung Jun Kim
    • Abby F. Dernburg
    Article Open Access