Key metalloproteinase-mediated pathways in the kidney

  • Justyna Wozniak
  • Jürgen Floege
  • Andreas Ludwig
Review Article


  • Vasculature

    A series of articles focusing on global humanitarian challenges in nephrology that contribute to widespread disparities in kidney health, including issues related to social injustices and environmental protection.

  • SARS-CoV-2

    This article series aims to highlight basic, clinical and psychological aspects of COVID-19 in nephrology as well as the impact of the pandemic on research and clinical trials.

  • Dialysis innovation

    This focus issue describes the limitations of current dialysis and vascular access modalities and highlights some of the innovative approaches that have potential to transform the lives of patients with kidney failure worldwide.

  • Genetics kidney

    This focus issue explores how the adoption of a precision medicine approach in nephrology could more closely align disease classification to pathophysiologic processes and aid the identification of therapeutic targets.


    • Inflammation is a known driver of diabetes and obesity-associated kidney disease. This Review describes the role of endogenous lipid mediators — specialized pro-resolving lipid mediators and branched fatty acid esters of hydroxy fatty acids — in the resolution of inflammation and explores how insights into their function could identify new targets for therapeutic intervention.

      • Eoin Brennan
      • Phillip Kantharidis
      • Catherine Godson
      Review Article
    • Acute kidney injury (AKI) is a common complication of COVID-19. This Review describes current understanding of the pathophysiology of COVID-19-associated AKI, examining potential mechanisms by which SARS-CoV-2 infection might induce direct and indirect effects on the kidney and non-specific factors, including haemodynamic changes and/or organ crosstalk, that may adversely influence kidney function.

      • Matthieu Legrand
      • Samira Bell
      • Vincenzo Cantaluppi
      Review Article
    • The AURORA 1 study reports that low-dose voclosporin added to standard immunosuppressive treatment improved rate of remission in patients with lupus nephritis. Further studies are needed to investigate the long-term efficacy and tolerability of voclosporin and to compare the effects of this treatment with those of low doses of tacrolimus or ciclosporin.

      • Gabriella Moroni
      • Claudio Ponticelli
      News & Views
    • Aquaporin 2 has an essential role in water reabsorption in the collecting duct. Here, the authors discuss novel insights in the field of aquaporin 2 regulation and how they might have implications for the treatment not only of water balance disorders but also of patients with autosomal dominant polycystic kidney disease.

      • Emma T. B. Olesen
      • Robert A. Fenton
      Review Article
    • Application of big data in nephrology could lead to new insights into kidney diseases, facilitate personalized medicine and improve patient care. This Review discusses the major sources of big data in nephrology and how they could be utilized in research and clinical practice.

      • Navchetan Kaur
      • Sanchita Bhattacharya
      • Atul J. Butte
      Review Article

Nature Careers