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This Comment article highlights the progress that has been made over the past 40 years since the discovery of HIV, and discusses the commitment needed to end the HIV/AIDS epidemic and the ongoing challenges.
This study reports the identification of the novel Candida auris-specific adhesin Scf1, which, together with the adhesin Iff4109, is a key mediator of surface association, infection and long-term colonization.
In this study, Yan et al. developed a broad-spectrum protein-free vaccine that protects against infection with bacterial and fungal nosocomial pathogens.
This Genome Watch highlights different tools and strategies used to enhance the quality of metagenome-assembled genomes (MAGs) generated in microbiome studies.
In this Review, Fishbein, Mahmud and Dantas discuss factors that influence restructuring of the gut microbiome on antibiotic exposure, and they explore promising therapeutic avenues aimed at minimizing antibiotic-induced damage to the microbiome or restoring the community structure post-treatment.
In this Review, de Nies, Kobras and Stracy examine the detrimental effects of antibiotics on the microbiota and the resulting associated infections. They delve into the interplay between antibiotic therapy, loss of colonization resistance, overgrowth of resistant bacteria and subsequent infections. They also discuss strategies to mitigate these risks and reduce antibiotic-associated infections.
In this Review, Russell and colleagues explore the interplay between immunity evolution from previous infections or vaccination and the evolution of seasonal influenza viruses. They explore functional constraints that limit virus evolution, within-host evolutionary processes that drive new variants and options for influenza virus control, including improving vaccine and antiviral effectiveness by overcoming viral and immunological barriers.
In this Review, Lockhart, Chowdhary and Gold discuss the global emergence and spread of three emerging antifungal-resistant fungi: Candida auris, azole-resistant Aspergillus fumigatus and Trichophyton indotineae, with the common thread that all three are currently emerging across the globe and have a high rate of acquired resistance.
