News & Comment

Zhang et al. report that angiogenesis in the chick embryo is supported by migrasomes — recently described organelles produced by migrating cells.

Cockburn et al. report that cells exiting the epidermal stem cell layer show a gradual progression of transcriptional changes during differentiation and retain the ability to divide once differentiation-committed.

The oncoprotein MYC undergoes multimerization to limit transcription–replication conflicts, thereby reducing the formation of DNA double-strand breaks in cancer cells.

In this World View, Felicity Davis discusses how efforts surrounding diversity, equity and inclusion (DEI) often serve to tick a mandatory box, rather than delivering a meaningful change in the DEI space.

Bera et al. demonstrate that increased viscosity of the surrounding fluid promotes cell migration, supporting tumour cell dissemination and tissue colonization in vivo.

Marina Chekulaeva describes the experiments that showed that microRNAs cause degradation of their target mRNAs.

Malka et al. uncover thousands of 5′ uncapped and polyadenylated transcripts (5′ UPTs) and describe their biogenesis through the alternative polyadenylation pathway. 5′ UPTs contribute to the proteome as non-canonical peptides with likely diverse biological functions.

Reyes et al. show that fibroblasts with properties of cellular senescence are present in healthy epithelial tissues and — by upregulating the senescence associated secretory phenotype (SASP) — they support stem-cell function and tissue repair.

Giovanni D’Angelo and Gioele La Manno present the concept of lipotypes, and suggest that lipid composition is an important regulator of cell fate.

Natascha Drude wanted to combine her academic work in drug development with clinical research. Here’s how she managed to bridge the divide.

This Comment draws attention to cellular protrusions as a source of extracellular vesicles (EVs). These protrusion-derived vesicles expand the repertoire of EVs, impacting current nomenclature and our understanding of EV functions in inter-cellular communication.

Liming Sun brings to attention paper by Li et al. (2012) reporting that necroptosis kinases, RIPK1 and RIPK3, form functional amyloids that regulate cell death signalling.

Zheng et al. show that calcium transients at the endoplasmic reticulum surface trigger condensation of FIP200 and the formation of ULK1 assemblies for autophagosome biogenesis.

Tan and Finkel report a novel phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway that is crucial for lysosome membrane repair.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is important for replication-fork reversal under replication stress, and its inhibition can abolish PARP-inhibitor resistance in cancer cells.

Kalkavan et al. show how drug-tolerant persister cells evade apoptosis by release of sublethal cytochrome c and activation of the integrated stress response.

Leilei Chen describes the discovery that adenosine-to-inosine editing by ADAR1 marks endogenous double-stranded RNA as self, to prevent it from triggering innate immunity.

Bishop and Hawley argue against a direct relationship between changes in mRNA levels and the abundance of the proteins they encode in skeletal muscles in response to exercise.

Steinhorst et al. show how calcium signal induced by salt stress is ‘decoded’ by plant roots to provide systemic response and to increase salt tolerance.

Yang, Zhu et al. describe temperature-dependent structural conformations of COOLAIR lncRNA and their impact on flowering time.