Vicky Summersby

Functions and regulation of mitochondrial calcium

Latest Reviews

  • Review Article |

    The distribution of lipids largely depends on their non-vesicular transport by lipid transfer proteins (LTPs). Recent progress in understanding the mechanisms of LTPs, including the appreciation of their widespread activity at membrane contact sites, has provided novel insights into the regulation of lipid trafficking and how it impacts pathophysiology.

    • Louise H. Wong
    • , Alberto T. Gatta
    •  & Tim P. Levine
  • Review Article |

    Actin and microtubules are essential for key cellular processes, including cell polarization, migration and division. Although their cellular roles are distinct, actin and microtubules also extensively influence each other’s dynamics and organization. This crosstalk encompasses multiple mechanisms and involves various crosslinkers, motors and regulatory proteins as well as mechanical cooperation.

    • Marileen Dogterom
    •  & Gijsje H. Koenderink
  • Review Article |

    Cellular stress responses primarily serve to rectify stress-associated damage. However, these responses are also coupled with the generation of various signals that are transmitted to the cellular microenvironments or even across tissues. This communication generally supports the maintenance of systemic homeostasis but can also result in pathology.

    • Lorenzo Galluzzi
    • , Takahiro Yamazaki
    •  & Guido Kroemer
  • Review Article |

    The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. Recent advances in structural biology techniques have provided insight into how amyloid structure may affect the ability of fibrils to spread in a prion-like manner and into their roles in disease.

    • Matthew G. Iadanza
    • , Matthew P. Jackson
    • , Eric W. Hewitt
    • , Neil A. Ranson
    •  & Sheena E. Radford
  • Review Article |

    The cleavage of microRNA (miRNA) precursors by Drosha and Dicer and their loading with Argonaute proteins into RNA-induced silencing complexes are key steps in miRNA biogenesis. Recent studies have clarified the mechanisms of action of these molecular machines and discovered non-canonical miRNA biogenesis pathways.

    • Thomas Treiber
    • , Nora Treiber
    •  & Gunter Meister
  • Review Article |

    Endocytosed membrane proteins can either be degraded in the lysosome or recycled back to the membrane. This decision, which has an impact on protein levels, spatial distribution and function, is controlled by recycling machineries at the endosome that recognize and segregate cargo destined for recycling, thereby preventing its degradation.

    • Peter J. Cullen
    •  & Florian Steinberg

News & Comment

  • Research Highlight |

    Endothelial cells in white adipose tissue communicate with adipocytes through extracellular vesicles, relaying systemic metabolic information.

    • Paulina Strzyz
  • Journal Club |

    Adriano Aguzzi discusses the endeavours of the Gitler team to identify the causes underlying the fatal human neurological disease amyotrophic lateral sclerosis (ALS).

    • Adriano Aguzzi
  • Research Highlight |

    DNA double-strand breaks at active genes are repaired by a dedicated homologous recombination mechanism involving R-loop formation and RAD52 recruitment.

    • Eytan Zlotorynski
  • Research Highlight |

    Nature Reviews Molecular Cell Biology congratulates the winners of the 2018 Lasker Foundation Awards.

    • Paulina Strzyz
  • Journal Club |

    The introduction of DNA-chain terminators for sequencing by Fred Sanger enabled the early genome sequencing projects.

    • George G. Brownlee
  • Research Highlight |

    The kinase ATR senses the completion of DNA replication and controls the S/G2 cell-cycle transition.

    • Michelle Trenkmann

Collection

Super-resolution microscopy

Bertocchi et al., Nature Cell Biology volume 19, pages 28–37 (2017).

Super-resolution microscopy

Popularization of super-resolution imaging techniques has allowed cell biologists to probe cell structure and function in previously unattainable detail. These methodologies continue to evolve, with new improvements that allow tailoring the available techniques to a particular need and application. This collection showcases primary research articles, reviews and protocols and highlights these recent developments by exemplifying the new, interesting applications of super-resolution microscopy as well as related tool development.

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