Vicky Summersby

Roles of linker histones in regulating chromatin structure and function

Latest Reviews

  • Review |

    Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes. Although the machineries that drive the formation of endocytic vesicle are intricate, an understanding of endocytosis is being unravelled at the molecular level.

    • Marko Kaksonen
    •  & Aurélien Roux
  • Review |

    Membrane lipids exhibit a remarkable diversity — they vary in structure and chemical properties, and their distribution between different membranes and their subcompartments is highly heterogeneous. Recent progress in studies of membrane lipids has broadened our understanding of how this diversity affects membrane properties and membrane-associated processes.

    • Takeshi Harayama
    •  & Howard Riezman
  • Review |

    Most eukaryotic cells contain a single centrosome with a pair of centrioles, which duplicate before mitosis. Defects in duplication lead to aberrant numbers of centrioles and centrosomes. Recent insights into mechanisms of centriole biogenesis and centriole number control are helping us to better understand the links between aberrant centrosome number and human disease.

    • Erich A. Nigg
    •  & Andrew J. Holland
  • Review |

    Recent studies that combine cell biology, structural and proteomic approaches have unravelled how ubiquitin is conjugated to damaged mitochondria through the PINK1–parkin pathway to promote mitophagy. The findings have revealed links between PINK1–parkin, antigen presentation and neuronal survival and have implications for the understanding of neurological disorders.

    • J. Wade Harper
    • , Alban Ordureau
    •  & Jin-Mi Heo
  • Review |

    Cells produce a wide variety of extracellular vesicles (subdivided into exosomes and microvesicles), which carry a multitude of cargoes, including proteins, lipids and nucleic acids. These vesicles have emerged as important means of cell–cell communication in physiology and disease, and their use in the clinic is now being explored.

    • Guillaume van Niel
    • , Gisela D'Angelo
    •  & Graça Raposo
  • Review |

    Recent proteome-wide studies have uncovered hundreds of RNA-binding proteins (RBPs) that lack conventional RNA-binding domains. These RBPs instead use intrinsically disordered regions, protein–protein interaction interfaces and enzymatic cores to bind RNA. Interestingly, some RBPs are regulated by RNA rather than regulate RNA.

    • Matthias W. Hentze
    • , Alfredo Castello
    • , Thomas Schwarzl
    •  & Thomas Preiss

News & Comment

  • Research Highlight |

    Fatty acid oxidation and increased acetyl-CoA levels act to suppress endothelial–mesenchymal transition.

    • Paulina Strzyz
  • Research Highlight |

    Developmental enhancers can function in an additive manner and are regulated by RNA polymerase II pausing and by the directionality of transcription.

    • Eytan Zlotorynski
  • Research Highlight |

    By editing of endogenous mRNAs, the RNA editing enzyme ADAR1 prevents interferon-induced translation shutdown and cell death, and virus-independent interferon induction in neuronal cells.

    • Eytan Zlotorynski
  • Journal Club |

    Philip Cohen highlights how two studies from the laboratory of Zhijian Chen, published in 2000 and 2001, started a new era in the study of signal transduction pathways and the roles of ubiquitin chains.

    • Philip Cohen
  • Research Highlight |

    Perturbation of phospholipid composition in intestinal stem cells (ISCs) results in increased cholesterol biosynthesis; excess cholesterol is a driver of ISC hyperproliferation, and consequently of intestinal hypertrophy and cancer.

    • Paulina Strzyz

Natureevents Directory