Long non-coding RNAs as flowers

Blooming lncRNAs

Inspired by the Consensus Statement by Mattick and co discussing definitions, and functions of lncRNAs as well as challenges and recommendations associated with studies of lncRNAs. 


  • Voices of the new generation

    Are you an early-career researcher/new principal investigator and are interested in sharing your experiences with others? NRMCB has opened a space to do just that! If you like the idea, please get in touch with us at nrm@nature.com with suggestions for potential content for this section.

  • Spanners with embryos

    Share your Tools of the Trade

    Are you an early-career researcher who is working with a cool tool or method? Would you like others to learn about it? Let us know! We are introducing Tools of the Trade articles to showcase the role of ECRs in driving technological advancements in molecular cell biology. Email us at nrm@nature.com the method/tool you'd like to write about and why it's important.

  • ECR initiative

    Nature Reviews Molecular Cell Biology is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is appropriately recognised. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process.

  • Colorful vesicles floating around

    Check out this new Collection from Nature Portfolio journals devoted to biology, function and clinical translation of extracellular vesicles, as well as associated technical developments that facilitate studies in this area.


    • Single-cell multi-omics methods are essential for characterizing cell states and types. The past decade has ushered in improvements in spatial resolution and computational data integration and in new omics modalities. Consequently, single-cell multi-omics have advanced fundamental and translational research, including, for example, in production of cell atlases and in tumour immunology therapeutics.

      • Alev Baysoy
      • Zhiliang Bai
      • Rong Fan
      Review Article
    • Actin is most frequently associated with cell migration and shape control. However, actin has a multitude of other cellular roles, including regulating the function and dynamics of organelles. This Review discusses a plethora of actin functions in mitochondrial biology.

      • Tak Shun Fung
      • Rajarshi Chakrabarti
      • Henry N. Higgs
      Review Article
    • Structural maintenance of chromosomes (SMC) complexes, which connect regulatory DNA elements, form chromatin loops and hold together sister chromatids, are required for accurate chromosome segregation and of control transcription, replication and DNA repair. It has recently become clear that SMC complexes also control nuclear organization by counteracting clustering between similar chromatin regions.

      • Claire Hoencamp
      • Benjamin D. Rowland
      Review Article
    • Skeletal muscles show high metabolic flexibility and functional plasticity in their response to different exercise modalities. Recent findings have advanced our understanding of signalling, transcriptional and epigenetic mechanisms that regulate muscle adaptation to exercise and their impact on muscle physiology.

      • Jonathon A. B. Smith
      • Kevin A. Murach
      • Juleen R. Zierath
      Review Article
    • Phospholipids are asymmetrically distributed between membrane leaflets but change their location in various biological processes, which requires designated proteins — flippases and scramblases. Recent insights into the functional mechanisms of these proteins pave the way for better understanding of the roles of membrane asymmetry and the (patho)physiological consequences of its disruption.

      • Takaharu Sakuragi
      • Shigekazu Nagata
      Review Article
  • Rogers et al. provide evidence that hypoxia is beneficial in mammalian ageing, extending the lifespan of prematurely ageing mice.

    • Paulina Strzyz
    Research Highlight
  • Subunits of the SWI/SNF chromatin remodelling complexes ‘bookmark’ cell-type specifying genes during mitosis to allow their timely reactivation upon mitosis exit.

    • Eytan Zlotorynski
    Research Highlight
  • In this Tools of the Trade article, Nouf Laqtom (at the Abu-Remaileh lab) describes the LysoIP system used to tag and isolate lysosomes for multi-omic approaches and to determine their composition under physiological and pathological states.

    • Nouf N. Laqtom
    Tools of the Trade
  • Quality control of misfolded glycosylphosphatidylinositol-anchored proteins (GPI-APs) does not occur through ER-associated degradation, as the lipid anchor precludes retrotranslocation across the ER membrane. Instead, different organisms have developed distinct solutions to prevent the accumulation of misfolded GPI-APs.

    • Leticia Lemus
    • Ramanujan S. Hegde
    • Veit Goder
  • Transport of the developmental mRNA oskar to its destination at the posterior pole of the Drosophila embryo relies on the two dsRNA-binding proteins Egalitarian and Staufen that promote switching between the motor proteins dynein and kinesin.

    • Lisa Heinke
    Research Highlight
  • A new study collaboratively delivered by Valentina Greco’s and Smita Krishnaswamy’s labs provides new insight into patterns of calcium signalling in epithelial tissues using intravital imaging of the basal layer of the mouse epidermis.

    • Paulina Strzyz
    Research Highlight
The sea with lipid rafts

Lipids and membranes

This article series brings together Reviews that focus on key advances in understanding membrane biology as well as the regulation and functions of their lipid components, including their roles as bioactive molecules and their interplay with metabolism.


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