Simon Bradbrook

Sending a TCR message

Regulatory mechanisms involved in T cell receptor signalling.

Latest Reviews

  • Review Article |

    This Review examines the functions of a specialized population of macrophages that make direct contact with or are found within one cell thickness of the abluminal surface of blood vessels in various tissues during both steady-state conditions and pathological processes.

    • Antonio Lapenna
    • , Michele De Palma
    •  & Claire E. Lewis
  • Review Article |

    IL-2 is well known for its crucial role in driving T cell responses. Now, with improved knowledge of its expression, signalling and regulation, the therapeutic potential of administering or inhibiting IL-2 is being explored to treat autoimmune diseases, infectious diseases and cancer.

    • Rosanne Spolski
    • , Peng Li
    •  & Warren J. Leonard
  • Review Article |

    CD4+ T cells provide help to CD8+ T cells via lymph node-resident dendritic cells. In this Review, the authors discuss the molecular nature of help signals and how they can be harnessed to improve cancer immunotherapy.

    • Jannie Borst
    • , Tomasz Ahrends
    • , Nikolina Bąbała
    • , Cornelis J. M. Melief
    •  & Wolfgang Kastenmüller
  • Review Article |

    This Review explores the challenges and opportunities of taking CARs down new therapeutic roads, in terms of developing chimeric antigen receptors (CARs) for treating infectious disease, autoimmunity and transplant rejection.

    • Colby R. Maldini
    • , Gavin I. Ellis
    •  & James L. Riley
  • Review Article |

    Histone deacetylases (HDACs) and histone acetyltransferases mediate reversible acetylation of histones and many other non-histone proteins to regulate gene expression and protein function. Here, the authors describe the myriad activities of HDACs in CD4+ T cells and the potential use of HDAC inhibitors as therapeutics for immune-mediated diseases.

    • Wilfried Ellmeier
    •  & Christian Seiser
  • Review Article |

    Here, the authors examine the functions of different subsets of invariant natural killer T (iNKT) cells. They explain how iNKT cells contribute to tissue homeostasis and protection against infection, with a focus on the liver, intestine, lungs and adipose tissue.

    • Catherine M. Crosby
    •  & Mitchell Kronenberg

News & Comment

  • Research Highlight |

    A regulatory B cell subset has been identified that is characterized by the expression of LAG3. In response to TLR stimulation, these LAG3+ B cells produce IL-10.

    • Alexandra Flemming
  • Research Highlight |

    RNA degradasome components metabolize mitochondrial double-stranded RNA and prevent aberrant activation of innate sensors in the cytosol.

    • Yvonne Bordon
  • Journal Club |

    Adrian Liston describes two papers by Nicole Le Douarin and colleagues from the 1980s that used a chick–quail graft system to show the existence of dominant T cell tolerance.

    • Adrian Liston
  • Research Highlight |

    A combination of TORC1 inhibitors increases immune responses to vaccines and decreases overall infection rates in the elderly.

    • Alexandra Flemming


Cancer immunotherapy

A Focus issue of Nature Reviews Immunology highlighting the latest advances in cancer immunotherapy, including checkpoint blockade, cancer vaccines and modulation of the tumour microenvironment to improve the efficacy of immunotherapy.

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