November 2014 marks the 10th anniversary of the launch of Nature Reviews Gastroenterology & Hepatology, originally published under the title ofNature Clinical Practice Gastroenterology & Hepatology. To celebrate this milestone, we present a special Anniversary issue. These specially commissioned articles written by members of our international Advisory Board, together with a special infographic, summarize the major advances in gastroenterology and hepatology over the past 10 years alongside predictions for the future.