A new study published in Nature Communications has reported an increased abundance of Enterobacteriaceae in IL10−/− mice (IL-10 deficiency results in spontaneous and chronic colitis) compared with healthy controls. Results from Escherichia coli RNA sequencing in IL10−/− mice revealed an altered expression profile, which was attributed to intestinal adaptation. Moreover, inflammation and carcinogenesis appeared to modify the expression of tumour-promoting genes in the E. coli pks island (a region encoding polyketide-peptide genotoxins). The authors believe that inflammation in these mice underpins Enterobacteriaceae colonization and affects expression of genes related to tumour development.
References
Arthur, J. C. et al. Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer. Nat. Commun. doi:10.1038/ncomms5724
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The importance of inflammation in bacteria-induced CRC. Nat Rev Gastroenterol Hepatol 11, 642 (2014). https://doi.org/10.1038/nrgastro.2014.171
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DOI: https://doi.org/10.1038/nrgastro.2014.171