Reviews & Analysis

Primary central nervous system lymphoma (PCNSL) is a diffuse large B cell lymphoma that exclusively affects the brain, spinal cord, meninges or eyes. This illustrated PrimeView accompanies the Primer article on PCNSL by Ferreri and colleagues.

This Primer summarizes the epidemiology, pathophysiology, diagnosis and treatment of primary central nervous system lymphoma. This Primer also reviews future research avenues and the effect that this disorder has on the quality of life of patients.

This illustrated PrimeView summarizes the diagnosis, mechanisms, epidemiology and treatment of acute graft-versus-host disease, and accompanies the Primer article on this topic by Malard et al.

Acute graft-versus-host disease can occur after allogeneic haematopoietic cell transplantation. This Primer summarizes the epidemiology, pathophysiology, diagnosis, prevention and treatment of this disorder. This Primer also reviews future research avenues and the effect this disorder has on patients’ quality of life.

This PrimeView highlights the epidemiology and risk factors of child and adolescent obesity, and summarizes the mechanisms, diagnosis, management and prevention of this condition.

Worldwide, the prevalence of obesity in children and adolescents remains high or is increasing. This Primer by Lister and colleagues discusses the epidemiology, mechanisms, diagnosis, prevention and management of obesity in this age group. The authors also highlight patient quality of life and areas for further research.

This PrimeView highlights the mechanisms, epidemiology, diagnosis, and management of young-onset colorectal cancer.

Young-onset colorectal cancer occurs in individuals younger than 50 years and is increasing in incidence worldwide. This Primer provides an overview of the epidemiology, diagnosis, screening, prevention, pathophysiology and management of this cancer and its impact on patient quality of life.

This PrimeView highlights the pathophysiology of Helicobacter pylori infection and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Malfertheiner and colleagues.

Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.

This PrimeView highlights the epidemiology of chikungunya fever and summarizes its pathophysiology, diagnosis and management. It accompanies the Primer on this topic by Bartholomeeusen and colleagues.

Chikungunya fever is an acute febrile illness caused by chikungunya virus, a mosquito-borne alphavirus. This Primer by Bartholomeeusen and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of chikungunya fever, and discusses patient quality of life and open research questions for this condition.

This PrimeView highlights the diagnosis of intracerebral haemorrhage and accompanies the Primer article on the same topic by Cordonnier and colleagues.

This Primer by Cordonnier and colleagues describes the epidemiology, aetiology, pathophysiology, diagnosis and treatment of intracerebral haemorrhage.

This PrimeView highlights the pathogenesis of monogenic diabetes, a group of predominantly early-onset disorders that are caused by single genetic alterations.

Monogenic diabetes encompasses forms of diabetes that result from a single pathogenic genetic alteration and usually have an early onset. This Primer gives an overview of the epidemiology, pathophysiology, diagnosis and treatment of these conditions, as well as patient quality of life and open research questions.

This PrimeView summarizes the pathophysiology of fetal alcohol spectrum disorders, a group of conditions that occur in children exposed prenatally to alcohol.

Fetal alcohol spectrum disorders (FASD) are characterized by neurodevelopmental impairment with or without facial dysmorphology, congenital anomalies and poor growth. This Primer discusses the epidemiology, pathophysiology, diagnosis and treatment of FASD.

This PrimeView highlights the diagnosis of pre-eclampsia and summarizes its epidemiology, pathophysiology and management. It accompanies the Primer on this topic by Dimitriadis and colleagues.

Pre-eclampsia is a life-threatening disease of pregnancy and a leading cause of maternal and neonatal morbidity and mortality. This Primer by Dimitriadis and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of pre-eclampsia, and discusses patient quality of life and open research questions for this condition.