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An optical technique is developed that extends the capabilities of fluorescent nanosensors into previously inaccessible ultradeep in vivo locations, including the brain, without the use of fibre optic or cranial window insertion.
Activation of the STING pathway in antigen-presenting cells has been proposed as a strategy to stimulate the adaptive immune response against tumours, but its clinical application is hampered by the instability, low specificity and low cytosolic entry of natural STING agonists. Here the authors present a platform for targeted ultrasound-mediated cytosolic delivery of STING agonists that shows efficacy in different animal tumour models and improves the response to checkpoint blockade therapies.
A metal–organic-framework-derived nanoporous carbon with intrinsically fast sorption kinetics and excellent photothermal properties enables high-yield, solar-driven atmospheric water harvesting in arid areas.
Pyroptosis is a programmed cell death mechanism relevant in cancer therapy that can be triggered by endocytic organelle stress, but is challenging to induce in a controlled manner. In this paper the authors engineer a library of ultra-pH-sensitive nanophotosensitizers that can target specific endocytic organelles and elicit pyroptotic cancer cell death in a controlled fashion.
Biocompatible core–shell quantum dots and superconducting nanowire single-photon detector enable non-invasive one-photon excitation fluorescence imaging at 1,880 nm for in vivo imaging at 1,100 μm depth.
Friction and wear at the atomic scale are hard to capture in experiment. Real-time in situ investigations of the countermotion of two touching tungsten asperities by means of high-resolution transmission electron microscopy unveil discrete stick–slip friction and molecular dynamics simulations provide insights into the sliding pathway of the atoms at the interface.
In vivo delivery of the CRISPR/Cas system is a promising cancer therapy approach, but its efficacy is hampered by low penetrability of nanoparticles in the stiff tumour tissue. Here the authors use dendrimer lipid nanoparticles to couple PD-L1 gene editing with knockdown of FAK, a protein involved in cell adhesion, showing that modulation of the mechanical properties of tumour cells leads to enhanced gene editing and tumour growth inhibition in four different animal models.
A nanomagnetic artificial spin ice array with two types of nanomagnets can host both magnetic macrospins and vortices. This enables highly reconfigurable magnon behaviour, which is leveraged for hardware neuromorphic computation.
Nitrate, a common pollutant in wastewater and groundwater, has been efficiently converted into valuable ammonia products via an electrochemical method using Ru-dispersed Cu nanowire as the catalyst.
The performance of nanostructured metal catalysts in acetylene hydrochlorination is governed by an interplay of nuclearity, coordination and host effects. The central activity descriptor is identified as the acetylene adsorption energy.
The ultrathin thickness, high pore density and short interpore distance of a COF monolayer endow an extremely low membrane resistance and strong pore–pore coupling, which greatly improves the membrane-based osmotic power generation.
A robust all-organic interfacial protective layer towards ultrahigh-rate and large-capacity Li metal anodes is proposed by rational integration of porous polymer-based molecular brushes with single-ion-conductive lithiated Nafion.
The incorporation of electron transport layers based on single-crystalline TiO2 rhombohedral nanoparticles enables the realization of stable and efficient large-area perovskite solar cell modules.
A microscopic robotic device is remotely controlled in two dimensions in all three degrees of freedom independently by the interaction between unfocused light and four plasmonic nanoantennas.
A Cu2+-crosslinked chitosan material with unique 1 nm hexagonal nanochannels is synthesized and applied as a high-performance and alkaline-stable hydroxide exchange membrane.