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Characterization of the myotis bat morbillivirus shows that infection in human cells is restricted by innate immune responses in vitro and cross-neutralization by sera from measles, mumps and rubella vaccinees.
An artificial intelligence system called BacterAI uses laboratory robots to learn the logic of microbial metabolism. BacterAI plans experiments autonomously and does not require any prior knowledge.
The microbiota associated with the rice plant panicle can protect against fungal disease via modulating host leucine production and induction of apoptosis-like cell death in the pathogen.
Inhibition of fatty acid biosynthesis re-sensitizes colistin-resistant clinically relevant bacteria in vivo by inducing stress responses and altering membrane composition.
The cryogenic electron microscopy structure of the Pseudomonas aeruginosa cell division complex and antibiotic drug target, FtsWIQBL, suggests a possible activation mechanism.
Sampling beneath the Ross Ice Shelf in Antarctica coupled to global sequencing datasets reveals an important but overlooked contributor to deep ocean carbon and sulfur cycles.
The autophagy receptor SHISA9 balances innate immune responses during viral infection by controlling the levels of inhibitor of nuclear factor κB kinase subunit epsilon to restrict pathogenic inflammation in the central nervous system.
Statins have anti-cancer effects that are modulated by the gut commensal Lactobacillus reuteri and the tryptophan metabolite, indole-3-lactic acid, in mice and humans.
Faecal metagenomics and serum metabolomics reveal compositional and functional alterations in the gut microbiota of women with anorexia nervosa, and faecal transplants could transfer an anorexia-associated phenotype to germ-free mice.
Metagenomics and Hi-C proximity-ligation sequencing show that viruses in dense microbial communities can interact with multiple, distantly related microbial hosts.
Fc–Fc gamma receptor interactions and alveolar macrophages contribute to ancestral vaccine-induced control of infection with SARS-CoV-2 variants in mice.
Comparison of mucosal and systemic immunity after vaccination with the live-attenuated vaccine sCPD9, mRNA vaccine BNT162b2 or an adenovirus-vectored vaccine following SARS-CoV-2 challenge in hamsters.
ProBac-seq is a method that uses libraries of DNA probes and commercial microfluidics for single-cell RNA-seq, leveraged here to show heterogeneous gene expression in clonal bacterial cultures including variable toxin expression in an agricultural strain of Clostridium.
Detection of persistent replication-competent HIV in monocytes from virologically suppressed people with HIV indicates that monocytes have a role as a latent reservoir.