Xikun Zhou

TesG is a type I secretion effector of Pseudomonas aeruginosa that suppresses the host immune response during chronic infection

Latest Research

  • Article |

    By combining a deep mutational scanning strategy with molecular modelling, electron microscopy as well as cellular and biochemical approaches, the authors identify key amino acids in the C-terminal domain of the Zika virus envelope protein (E) that regulate viral replication in mosquito and human cells.

    • Yin Xiang Setoh
    • , Alberto A. Amarilla
    • , Nias Y. G. Peng
    • , Rebecca E. Griffiths
    • , Julio Carrera
    • , Morgan E. Freney
    • , Eri Nakayama
    • , Shinya Ogawa
    • , Daniel Watterson
    • , Naphak Modhiran
    • , Faith Elizabeth Nanyonga
    • , Francisco J. Torres
    • , Andrii Slonchak
    • , Parthiban Periasamy
    • , Natalie A. Prow
    • , Bing Tang
    • , Jessica Harrison
    • , Jody Hobson-Peters
    • , Thom Cuddihy
    • , Justin Cooper-White
    • , Roy A. Hall
    • , Paul R. Young
    • , Jason M. Mackenzie
    • , Ernst Wolvetang
    • , Jesse D. Bloom
    • , Andreas Suhrbier
    •  & Alexander A. Khromykh
  • Article |

    The isolation and characterization of seven monoclonal antibodies that recognize the lateral surface of the influenza virus neuraminidase (NA) head reveal that, even in absence of NA-inhibiting activity, anti-NA antibodies can provide protection and drive antigenic drift at the lateral surface of the NA.

    • Atsuhiro Yasuhara
    • , Seiya Yamayoshi
    • , Maki Kiso
    • , Yuko Sakai-Tagawa
    • , Michiko Koga
    • , Eisuke Adachi
    • , Tadashi Kikuchi
    • , I-Hsuan Wang
    • , Shinya Yamada
    •  & Yoshihiro Kawaoka
  • Article |

    Here, the authors developed an automated, high-throughput method for the sorting of single live cells based on their functional phenotype for downstream genomics or cultivation. Application of the platform to murine gut microbiota samples identified a diverse community of mucin degraders.

    • Kang Soo Lee
    • , Márton Palatinszky
    • , Fátima C. Pereira
    • , Jen Nguyen
    • , Vicente I. Fernandez
    • , Anna J. Mueller
    • , Filippo Menolascina
    • , Holger Daims
    • , David Berry
    • , Michael Wagner
    •  & Roman Stocker

News & Comment

  • Comment |

    Innovations in teaching STEM subjects can help build critical science literacy and address global economic needs. Virology teachers and researchers are actively developing and integrating innovative educational materials for students, creating engaging teaching programs and improving information platforms for the general public.

    • Esperanza Gomez-Lucia
    • , Christopher H. Logue
    • , Marek S. Szyndel
    •  & Rob Lavigne
  • Correspondence |

    • Dimitry Y. Sorokin
    • , Kira S. Makarova
    • , Ben Abbas
    • , Manuel Ferrer
    • , Peter N. Golyshin
    • , Erwin A. Galinski
    • , Sergio Ciorda
    • , María Carmen Mena
    • , Alexander Y. Merkel
    • , Yuri I. Wolf
    • , Mark C. M. van Loosdrecht
    •  & Eugene V. Koonin
  • News & Views |

    Severe fever with thrombocytopenia virus is an emerging, highly lethal tick-borne pathogen with growing impact. In this issue of Nature Microbiology, two papers make major progress towards a better understanding of its so far incompletely understood mechanisms of virulence.

    • Jennifer Deborah Wuerth
    •  & Friedemann Weber
  • News & Views |

    Bacteria have previously been assumed to cope with environmental stress by tuning their total number of active ribosomes. Instead, a study in this issue of Nature Microbiology shows that from a heterogeneous pool of ribosomes, Vibrio vulnificus uses ribosomes with a particular ribosomal RNA variant to translate upregulated stress response mRNAs.

    • Kathrin Leppek
    •  & Maria Barna

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