Volume 9

  • No. 4 April 2024

    How body-fluid vesicles block viral infection

    This image shows fluorescently labelled extracellular vesicles from semen (red) binding to Axl (green), a broadly expressed phosphatidylserine-binding receptor. This interaction interferes with infection by viruses exposing phosphatidylserine to exploit the immunosuppressive uptake mechanism of apoptotic membranes. Given their abundance in semen and saliva, extracellular vesicles may serve as an innate defence against sexual or oral transmission of viruses applying apoptotic mimicry such as Zika, Chikungunya or Ebola.

    See Groß et al.

  • No. 3 March 2024

    Vectors of the cadaver decomposition microbiome

    Decomposing remains, whether human or other animal, are attractive to organisms across the tree of life because they are concentrated sources of nutrients and moisture. Blow flies (likely to be Chrysomya rufifacies in this photo), for which larval stages are obligate flesh feeders, are key vectors of a specialist carrion decomposer microbial network that appears universal across terrestrial environments.

    See Burcham et al.

  • No. 2 February 2024

    Visualizing Tc toxin release

    This image shows type 10 secretion system (T10SS)-mediated Tc toxin release by Yersinia entomophaga, as captured by cryo-electron tomography. Spanin-mediated membrane fusion triggers bacterial lysis and the explosive discharge of pre-assembled toxins by a subset of the bacterial population.

    See Sitsel et al.

  • No. 1 January 2024

    Fungal vesicles activate host immunity

    This image shows confocal microscopy of macrophages with the DNA-sensing enzyme cGAS (GFP) translocating from the nucleus to the cytosol in response to the phagocytosis of extracellular vesicles isolated from the fungal pathogen Candida albicans.

    See Harding et al.