Reviews & Analysis

Insight into the molecular mechanism of rapamycin's immunosuppressive effects provides the basis for a novel approach to regulating therapeutic gene expression (pages 1028-1032).

A genetic defect in the HIV-1 co-receptor provides resistance to infection.

Altered microsatellite DNA in the blood of cancer patients may provide a novel method for tumor detection (pages 1033-1037).

High-resolution X-ray computed tomography reveals the three-dimensional structure of microscopic biological tissue and has great clinical potential if the X-ray dose can be reduced (pages 933–935).

Recent evidence suggests that Chlamydia bacteria may play an etiological role in the formation of atherosclerotic plaques.

Seroepidemlologlcal evidence from two new serologlcal assays supports a role for HHV8 In Kaposi's sarcoma (pages 918–928).

Manipulating the immune system with DNA vaccines shows promise for protecting against pathogens and suppressing autoimmune disease (pages 888–905).

An unconventional operation for treating end-stage heart failure may prove beneficial for some patients waiting for heart transplants.

Stochastic resonance may be just a few steps away from a practical application to cochlear implants for treating deafness (pages 928–932).

A bacteriophage mediates the horizontal transfer of virulence genes between Vibrio cholerae with broad implications for the emergence of pathogenic strains.

Defining the molecular pathways of Alzheimer's disease raises new possibilities for treatment (pages 864–875).

Emerging technologies hold promise for correcting refractive errors of the eye.

Lyophilized macromolecules complexed with zinc and encapsulated within degradable microspheres are slowly released for at least one month (pages 795–799).

Mice lacking TNF receptors show increased neuronal damage in response to excitotoxins or cerebral ischemia implying that TNF is neuroprotective (pages 788–794).

Mutations in a human HOX gene have been found in patients with the limb deformity, synpolydactyly.

Nerve growth factor is a survival factor for memory B cells and is a potential target in the treatment of autoimmune disease.

Elevated levels of wild-type p53 in testicular tumors may contribute to their sensitivity to DNA damaging drugs and explain their high cure rate (pages 804–810).

Immunization with subunit antigens prevents rectal transmission of SIV in monkeys (pages 767–775).