Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Genetic vaccination: The advantages of going naked

Nature Medicine volume 2, pages 857–859 (1996)Cite this article

Manipulating the immune system with DNA vaccines shows promise for protecting against pathogens and suppressing autoimmune disease (pages 888–905).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Huygen, K. et al. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nature Med. 2, 893–898 (1996).

    Article  CAS  Google Scholar 

  2. Tascon, R.E. et al. Vaccination against tuberculosis by DNA injection. Nature Med. 2, 888–892 (1996).

    Article  CAS  Google Scholar 

  3. Waisman, A. et al. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nature Med. 2, 899–905 (1996).

    Article  CAS  Google Scholar 

  4. Pardoll, D.M. & Beckerleg, A.M. Exposing the immunology of naked DNA vaccines. Immunity 3, 165–169 (1995).

    Article  CAS  Google Scholar 

  5. Hohlfeld, R. & Engel, A.G. The immunobiology of muscle. Immunol. Today 15, 269–274 (1994).

    Article  CAS  Google Scholar 

  6. Bird, A. The essentials of DNA methylation. Cell 70, 5–8 (1992).

    Article  CAS  Google Scholar 

  7. Pisetsky, D.S. The immunologic properties of DNA. J. Immunol. 156, 421–423 (1996).

    CAS  PubMed  Google Scholar 

  8. Vandenbark, A.A. et al. Immunization with a synthetic T cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341, 541–544 (1989).

    Article  CAS  Google Scholar 

  9. Howell, M.D. et al. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246, 668–670 (1989).

    Article  CAS  Google Scholar 

  10. Kumar, V. & Sercarz, E. The involvement of TcR-peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178, 909–916 (1993).

    Article  CAS  Google Scholar 

  11. Kumar, V. & Sercarz, E. Dysregulation of potentially pathogenic self reactivity is crucial for the manifestation of clinical autoimmunity. J. Neurosci. Res. (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics University of California, Los Angeles, Los Angeles, California, 90095-1489, USA

    Vipin Kumar & Eli Sercarz

Authors
  1. Vipin Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eli Sercarz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kumar, V., Sercarz, E. Genetic vaccination: The advantages of going naked. Nat Med 2, 857–859 (1996). https://doi.org/10.1038/nm0896-857

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0896-857

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing