Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Controlled release of a therapeutic protein

Lyophilized macromolecules complexed with zinc and encapsulated within degradable microspheres are slowly released for at least one month (pages 795–799).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Langer, R. New methods of drug delivery. Science 249, 1527–1533 (1990).

    Article  CAS  Google Scholar 

  2. Johnson, O.F.L. et al. A month-long effect from a single injection of microencapsulated human growth hormone. Nature Med. 2, 795–799 (1996).

    Article  CAS  Google Scholar 

  3. Langer, R. & Folkman, J. Polymers for the sustained-release of proteins and other macromolecules. Nature 263, 797–800 (1976).

    Article  CAS  Google Scholar 

  4. Stannett, V.T., Koros, W.J., Paul, D.R., Lonsdale, H.K. & Baker, R.W. Recent advances in membrane and science technology. Adv. Poly. Sci. 32, 69–121 (1979).

    Article  CAS  Google Scholar 

  5. Langer, R. 1994 Whitaker lecture: Polymers for drug delivery and tissue engineering. Ann. Biomed. Eng. 23, 101–111 (1995).

    Article  CAS  Google Scholar 

  6. Polverini, P., Cotran, R., Gimbrone, M. & Unanui, E. Activated macrophages induce vascular proliferation. Nature 269, 804–806 (1977).

    Article  CAS  Google Scholar 

  7. Schor, A.M. et al. Importance of a collagen substratum for stimulation of capillary endothelial cell proliferation by tumor angiogenesis. Int. J. Cancer 245, 225–234 (1979).

    Article  Google Scholar 

  8. Ogawa, Y., Yamamoto, M., Okada, H., Yashiki, T. & Shimamoto, T. A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid and copoly(lactic/glycolic acid). Bull. Chem. Pharm. 36, 1095–1103 (1988).

    Article  CAS  Google Scholar 

  9. Costantino, H., Langer, R. & Klibanov, A. Solid-phase aggregation of proteins under pharmaceutically relevant conditions. J. Pharm. Sci. 83, 1662–1666 (1994).

    Article  CAS  Google Scholar 

  10. Hageman, M.J., Bauer, J.M., Possert, P.L. & Darrington, R.T. Preformulation studies oriented toward sustained delivery of recombinant somatotropins. J. Agric. Food Chem. 40, 348–355 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Langer, R. Controlled release of a therapeutic protein. Nat Med 2, 742–743 (1996). https://doi.org/10.1038/nm0796-742

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0796-742

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing