News & Views

Autoantigen administration in an animal model of diabetes prevents development of the disease even after insulitis is established (pages 1348–1353).

NMDA receptor antagonists attenuate hearing loss induced by the excitotoxic action of aminoglycoside antibiotics (page 1338–1343).

Expression of a death factor by tumor cells may explain their escape from immune attack (pages 1361–1366).

Components of the hedgehog signaling pathways play key roles during embryonic development and in several human diseases.

A novel type of cell secreting norepinephrine resides in the mammalian heart.

Permanent acceptance of a skin xenograft was achieved by induction of tolerance in the recipient (pages 1211–1216).

Crystal structures of the assemblin proteinase should contribute to the development of new drugs against cytomegalovirus.

Partial liquid ventilation with perfluorocarbons has clinical potential for improving lung function in patients with respiratory failure.

A recent study suggests differences in kappa-opioid analgesia between men and women (pages 1248–1250).

Several forms of a paraoxonase enzyme provide different degrees of protection against organophosphate chemicals.

Cortical stimulation may prove useful in the development of interventions to alleviate impaired swallowing following brain injury (pages 1217–1224).

Two novel methods have been developed to study lung anatomy and function using magnetic resonance imaging (pages 1236–1239).

Inactivation of an enzyme in the ubiquitin protein degradation pathway results in male sterility in mice.

Vaccination may prove to be a powerful adjunct therapy for treating drug addiction, but more studies are needed to determine its ultimate value (page 1129–1132).

Rapid advances in the science of spectroscopy are leading to new methods for the diagnostic imaging of human disease.

T-cell receptor peptide vaccines may hold promise as future therapy for multiple sclerosis (pages 1109–1115).

Neuroimaging of monozygotic twins with Tourette syndrome suggests that increased binding by dopamine D2 receptors contributes to the disease phenotype.

Identifying the mechanisms that regulate hair cell regeneration may contribute to developing treatments for hearing loss in humans (pages 1136–1139).

A promising drug study in a mouse model of chagas' disease raises hopes that a major health and socioeconomic problem can be eliminated.

Heart defects in NT-3 knockout mice implicate this neurotrophin in cardiac development.