Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

New adrenergic cells stimulate heart research

Nature Medicine volume 2, pages 1194–1195 (1996)Cite this article

A novel type of cell secreting norepinephrine resides in the mammalian heart.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Huang, M.-H. et al. An intrinsic adrenergic system in mammalian heart. J. Clin. Invest. 98, 1298–1303 (1996).

    Article  CAS  Google Scholar 

  2. Pollack, G.H. Cardiac pacemaking: An obligatory role of catecholamines? Science 196, 731–738 (1977).

    Article  CAS  Google Scholar 

  3. Zhou, Q.-Y., Quaife, C.J. & Palmiter, R.D. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374, 640–643 (1995).

    Article  CAS  Google Scholar 

  4. Thomas, S.A., Matsumoto, A.M. & Palmiter, R.D. Noradrenaline is essential for mouse fetal development. Nature 374, 643–646 (1995).

    Article  CAS  Google Scholar 

  5. Kobayashi, K. et al. Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice. J. Biol. Chem. 270, 27235–27243 (1995).

    Article  CAS  Google Scholar 

  6. LeDourin, N.M. in The Neural Crest (Cambridge Univ. Press, Cambridge, 1982).

    Google Scholar 

  7. Evans, G.A. Dissecting mouse development with toxigenetics. Genes Dev. 3, 259–263 (1989).

    Article  CAS  Google Scholar 

  8. Rugh, R. in The Mouse: Its Reproduction and Development (Oxford Univ. Press, New York, 1990).

    Google Scholar 

  9. Czyzyk-Krzeska, M.F. et al. Regulation of tyrosine hydroxylase gene expression in rat carotid body by hypoxia. J. Neurochem. 58, 1538–1546 (1992).

    Article  CAS  Google Scholar 

  10. Gonzalez, C. et al. Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci. 15, 146–153 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, University of Washington Seattle, Washington, 98195, USA

    Richard D. Palmiter

Authors
  1. Richard D. Palmiter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Palmiter, R. New adrenergic cells stimulate heart research. Nat Med 2, 1194–1195 (1996). https://doi.org/10.1038/nm1196-1194

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1196-1194

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing