Identifying the mechanisms that regulate hair cell regeneration may contribute to developing treatments for hearing loss in humans (pages 1136–1139).
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Navaratnam, D.S., Su, H.S., Scott, S. & Oberholtzer, J.C. Proliferation in the auditory receptor epithelium mediated by a cAMP-dependent signaling pathway. Nature Med. 2, 1136–1139 (1996).
Stone, L.S. Further experimental studies of the development of lateral line sense organs in amphibians observed in living preparations. J. Comp. Neurol. 68, 83–115 (1937).
Cruz, R.M., Lambert, P.R. & Rubel, E.W. Light microscopic evidence of hair cell regeneration after gentamicin toxicity in chick cochlea. Arch. Otolaryngol. Head Neck Surg. 13, 1058–1062 (1987).
Cotanche, D.A. Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Hear. Res. 30, 181–195 (1987).
Corwin, J.T. & Cotanche, D.A. Regeneration of sensory hair cells after acoustic trauma. Science 240, 1772–1774 (1988).
Ryals, B.M. & Rubel, E.W. Hair cell regeneration after acoustic trauma in adult Coturnix quail. Science 240, 1774–1776 (1988).
Cotanche, D.A., Lee, K.H., Stone, J.S. & Picard, D.A. Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage: A review. Anat. Embryol. 198, 1–18 (1993).
Oesterle, E.C., Tsue, T.T., Reh, T.A. & Rubel, E.W. Hair-cell regeneration in organ cultures of the postnatal chicken inner ear. Hear. Res. 70, 85–108 (1993).
Warchol, M.E., Lambert, P.R., Goldstein, B.J., Forge, A. & Corwin, J.T. Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science 259, 1619–1622 (1993).
Forge, A., Lin, L., Corwin, J.T. & Nevill, G. Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science 259, 1616–1619 (1993).
Rubel, E.W., Dew, L.A. & Roberson, D.W. Mammalian vestibular hair cell regeneration. Science 267, 701–707 (1995).
Lenoir, M. & Vago, P. Morphological indications of hair cell neodifferentiation in the organ of Corti of amikacin treated rat pups. Life Sci. 319, 269–276 (1996).
Tanyeri, H., Lopez, I. & Honrubia, V. Histological evidence for hair cell regeneration after ototoxic hair cell destruction with local application of gentamicin in the chinchilla crista ampullaris. Hear. Res. 89, 194–202 (1995).
Lambert, P.R. Inner ear hair cell regeneration in a mammal: Identification of a triggering factor. Laryngoscope 104, 701–718 (1994).
Yamashita, H. & Oesterle, E.C. Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor. Proc. Natl. Acad. Sci. USA 92, 3152–3155 (1995).
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Rubel, E., Stone, J. Stimulating hair cell regeneration: On a wing and a prayer. Nat Med 2, 1082–1083 (1996). https://doi.org/10.1038/nm1096-1082
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DOI: https://doi.org/10.1038/nm1096-1082