News & Views

The connection between telomerase and oncogenesis may be more complex than initially thought (pages 1271–1274).

Amyloid-like aggregates of expanded polyglutamines are present in nuclei from affected neurons in Huntington and related neurodegenerative diseases.

New findings suggest that NF-κB proteins regulate osteoclast differentiation and are potential therapeutic targets for treating osteoporosis (pages 1285—1289).

Aging in women is accompanied by a reduced rate of skin wound healing, which is reversed by treatment with sex steroid hormones (pages 1209—1215).

Most uninfected partners of couples discordant for HIV infection show evidence of HlV-specific secretory IgA at mucosal sites (pages 1250–1257).

Conflicting results from anti-TNF trials in sepsis patients suggest that timely administration of TNF inhibitor drugs is crucial.

New findings suggest that PARP may be a perpetrator of brain injury following ischemic insult (pages 1089–1095).

An FGF-binding protein secreted by tumor cells suggests how bFGF may stimulate tumor angiogenesis (pages 1137–1140).

A recent report provides new insights into the early stages of infection in the prion diseases.

A novel anti-HIV strategy uses modified chemokines (intrakines), trapped within the endoplasmic reticulum, to block expression of HIV co-receptors on the host cell surface (pages 1110–1116).

Two mouse models of non-insulin-dependent diabetes show many similarities to the human disease (pages 1096–1101).

A novel mechanism used by pathogenic mycobacteria to enter macrophages (in low complement environments) may provide a new therapeutic target for the treatment of tuberculosis.

Examining the contribution of the FDA to the development of gene therapeutics.

Infusion of aging monkeys with growth hormone promotes proliferation of mammary epithelia, suggesting caution in treating the elderly with growth hormone supplements (pages 1141–1144).

Theiler's virus induces breakdown of tolerance to myelin and initiates a multiple sclerosis-like autoimmune disease in mice (pages 1133–1136).

The complete genome sequences of Escherichia coli and Helicobacter pylori provide insights into the biology of these species.

Cloned, cultured bovine adrenocortical cells are shown to engraft and form functional adrenocortical tissue in immunodeficient mice (pages 978–983).

New excitatory brain circuitry induced by injury: a leading pathophysiology or an also-ran in post-traumatic epilepsy ? (pages 990–996)

Leptin's role in pregnancy may help unravel the mechanisms by which this protein regulates obesity in humans (pages 1029–1033).

Treating neurodegenerative disease with drugs that inhibit the activity of caspases (proteases that regulate apoptosis) is a therapeutic avenue beginning to be explored.