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A tail retold

A recent report provides new insights into the early stages of infection in the prion diseases.

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References

  1. Fraser, H. & Dickinson, A.G. Targeting of scrapie lesions and spread of agent via the retino-tectal projection. Brain Res. 346, 32–41 (1985).

    Article  CAS  Google Scholar 

  2. Scott, J.R., Davies, D. & Fraser, H. Scrapie in the central nervous system: Neuroanatomical spread of infection and Sinc control of pathogenesis. J. Gen. Virol. 73, 1637–1644 (1992).

    Article  Google Scholar 

  3. Blattler, T. et al. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 389, 69–73 (1997).

    Article  CAS  Google Scholar 

  4. Bueler, H. et al. Mice devoid of PrP are resistant to scrapie. Cell 73, 1339–1347 (1993).

    Article  CAS  Google Scholar 

  5. Manson, J.C., Clarke, A.R., McBride, P.A. McConnell, I. & Hope, J. PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology. Neurodegeneration 3, 311–340 (1994).

    Google Scholar 

  6. Brander, S. et al. Normal host protein necessary for scrapie induced neurotoxicity. Nature 379, 339–343 (1996).

    Article  Google Scholar 

  7. Farquhar, C.F., Dornan, J., Somerville, R.A., Tunstall, A.M. & Hope, J. Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous tissue during the development of murine scrapie. J. Gen. Virol. 75, 455–504 (1994).

    Article  Google Scholar 

  8. Somerville, R.A. et al. Immunodetection of PrPSc in spleens of some scrapie-infected sheep but not BSE-infected cows. J. Gen. Virol. 78, 2389–2396 (1997).

    Article  CAS  Google Scholar 

  9. Kitamoto, T., Muramoto, T., Mohri, S., Doh-Ura, K. & Tateishi, J. Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease. J. Virol. 65, 6292–6295 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Fraser, H. & Dickinson, A.G. Pathogenesis of scrapie in mouse: the role of the spleen. Nature 226, 462–463 (1970).

    Article  CAS  Google Scholar 

  11. Fraser, H. & Farquhar, C.F. Ionising radiation has no influence on scrapie incubation period in mice. Vet. Microbiol. 13, 211–223 (1987).

    Article  CAS  Google Scholar 

  12. Kimberlin, R.H. & Walker, C.A. Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularily. J. Gen Virol. 67, 255–263 (1986).

    Article  Google Scholar 

  13. Kimberlin, R.H. & Walker, C.A. Pathogenesis of mouse scrapie: evidence for neural spread of infection to the CNS. J. Gen. Virol. 51, 183–187 (1980).

    Article  CAS  Google Scholar 

  14. Outram, G.W., Dickinson, A.G. & Fraser, H. Developmental maturation of susceptibility to scrapie in mice. Nature 241, 536–537 (1973).

    Article  CAS  Google Scholar 

  15. Brown;, K., Stewart, K., Bruce, M. & Fraser, H. Scrapie in immunodeficient mice. In Transmissible subacute encephalopathies: Prion disease. (Eds. Court, L. & Dodet, B. (Elsevier, 1996).

    Google Scholar 

  16. Brown, K., Stewart, K., Bruce, M. & Fraser, H. Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy. J. Gen Virol. 78, 2707–2710 (1997).

    Article  CAS  Google Scholar 

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Manson, J. A tail retold. Nat Med 3, 1087–1088 (1997). https://doi.org/10.1038/nm1097-1087

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