Theiler's virus induces breakdown of tolerance to myelin and initiates a multiple sclerosis-like autoimmune disease in mice (pages 1133–1136).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Miller, S.D. et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nature Med. 3, 1133–1136 (1997).
Fujinami, R. S. & Oldstone, M. B. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230, 1043–1045 (1985).
Gautam, A. M. et al. Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: Implications in induction of autoimmunity. Proc. Notl. Acad. Sci. USA 91, 767–771, 1994.
Wucherpfennig, K.W. & Strominger, J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80, 695–705 (1995).
Wucherpfennig, K.W. et al. Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2 restricted T cell clones from multiple sclerosis patients: Identity of key contact residues in the B-cell and T-cell epitopes. J. Clin. Invest., (in the press).
Brocke, S. et al. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature, 365, 642–644 (1993).
Friedmann, A., Frankel, G., Lorch, Y. & Steinman, L. Monoclonal anti I-A reverses chronic paralysis and demyelination in Theiler's virus infected mice: Critical importance of timing of treatment. J. Virol., 61, 898–903 (1987).
Miller, S.D. & Gerety, S.J. Immunologic aspects o Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. Semin. Virol. 1 263–272 (1990).
Yu, M., Johnson, J. M. & Tuohy, V. K. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183, 1777–1778 (1996).
Steinman, L. Multiple sclerosis: A coordinated im munological attack against myelin in the centra nervous system. Cell, 85, 299–302 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Steinman, L., Conlon, P. Viral damage and the breakdown of self-tolerance. Nat Med 3, 1085–1087 (1997). https://doi.org/10.1038/nm1097-1085
Issue Date:
DOI: https://doi.org/10.1038/nm1097-1085
This article is cited by
-
Epitope Spreading Is Rarely Found in Pemphigus Vulgaris by Large-Scale Longitudinal Study Using Desmoglein 2–Based Swapped Molecules
Journal of Investigative Dermatology (2012)
-
Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?
International Journal of Hematology (2002)
-
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
Nature Medicine (2000)