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Diabetes in midlife: Planting genetic time bombs

Nature Medicine volume 3, pages 1080–1081 (1997)Cite this article

Two mouse models of non-insulin-dependent diabetes show many similarities to the human disease (pages 1096–1101).

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References

  1. Leiter, E.H. & Herberg, L. The polygenetics of diabesity in mice. Diabetes Reviews 5, 131–148 (1997).

    Google Scholar 

  2. Stenbit, A.E. et al. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Med. 3, 1096–1101 (1997).

    Article  CAS  Google Scholar 

  3. Brüning, J.C. et al. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561–572 (1997).

    Article  Google Scholar 

  4. Patti, M.E. & Kahn, C.R. Lessons from transgenic and knockout animals about non-insulin-dependent diabetes meilitus. Trends in Endocrinology and Metabolism 7, 311–319 (1996).

    Article  CAS  Google Scholar 

  5. Defronzo, R.A. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37, 667–686 (1988).

    Article  CAS  Google Scholar 

  6. Accili, D. et al. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genet. 12, 106–109 (1996).

    Article  CAS  Google Scholar 

  7. Araki, E., Lipes, M.A. & Patti, M.E. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372, 186–190 (1994).

    Article  CAS  Google Scholar 

  8. Katz, E.B., Stenbit, A.E., Hatton, K., DePinho, R. & Charron, M.J. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377, 151–155 (1995).

    Article  CAS  Google Scholar 

  9. Terauchi, Y. et al. Development of non-insulin-dependent diabetes mellitus in double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes: Genetic reconstitution of diabetes as a polygenic disease. J. Clin. Invest. 99, 861–866 (1997).

    Article  CAS  Google Scholar 

  10. Chung, W.K. et al. Genetic modifiers of Lepr(fa) associated with variability in insulin production and susceptibility to NIDDM. Genomics 41, 332–344 (1997).

    Article  CAS  Google Scholar 

  11. Hales, C.N. & Barker, D.J.P. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595–601 (1992).

    Article  CAS  Google Scholar 

Download references

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  1. Departments of Medicine and Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QQ, U.K.

    Stephen O'Rahilly

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  1. Stephen O'Rahilly
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O'Rahilly, S. Diabetes in midlife: Planting genetic time bombs. Nat Med 3, 1080–1081 (1997). https://doi.org/10.1038/nm1097-1080

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