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Volume 3 Issue 3, March 2002

Gonorrhea infections are recurrent, indicative of an inadequate response and ineffective immunological memory. Boulton and Gray-Owen (page 229; see also Normark's News & Views on page 210) now demonstrate that the bacteria bind to CEACAM1 on CD4+ T cells, inhibiting their activation and proliferation.This could help explain both the general immunomalaise induced by gonococci and its ease of reinfection. Photo by I. C. Boulton.

Volume 3 Issue 3

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Commentary

  • One of the major goals of the WHO is elimination of polio, but the nature of rapidly evolving enteroviruses makes this task more complex than it initially appears.

    • Akio Nomoto
    • Isao Arita
    Commentary
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News & Views

  • Maintenance of a memory cell population is thought to be independent of antigen. However, it has now been shown that unless memory cells get some signals via MHC, they become functionally defective.

    • B. Rocha
    News & Views

  • The biochemical events that mediate inside-out signaling to β1 and β2 integrin receptors after TCR ligation are poorly understood. Using a transgenic mouse model, investigators have implicated an unexpected candidate, Rap1, as a key mediator of inside-out signaling in activated T cells.

    • Robert T. Abraham
    News & Views

  • The development of new experimental tools is helping to unravel the molecular secrets of cell differentiation. The identification, by gene chip technology, of a HMG box protein called TOX has yielded valuable information about thymocyte differentiation.

    • Dimitris Kioussis
    News & Views
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