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Volume 25 Issue 3, March 2024

Women in Neuroimmunology

March is Women’s History Month. This month’s issue celebrates the contributions of female neuroimmunologists.

For more information, see the Women in Immunology Collection

Image: nobeastsofierce Science / Alamy Stock Photo & Kiyoshi Takahase Segundo / Alamy Stock Photo. Cover design: Amie Fernandez

Editorial

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World View

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Research Highlights

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News & Views

  • Understanding the ontogeny of conventional dendritic cells (cDCs) is a major aim in the field. The fate of progenitors of the recently described subsets of mouse cDC2s (cDC2A and cDC2B) is determined in the bone marrow.

    • Charles-Antoine Dutertre
    News & Views
  • Intratumoral regulatory T (Treg) cells can suppress antitumor immunity. Unlike in splenic Treg cells, the H3K9me2 demethylase JMDJ1 seems to be induced, and is required for this function, in the tumor microenvironment, and targeting it with a small-molecule inhibitor can suppress tumor growth in mice.

    • Xuezheng Wang
    • Keji Zhao
    News & Views
  • Visceral adipose tissue hosts at least two populations of mature FOXP3+ regulatory T cells, which together can preserve systemic metabolism and control inflammation.

    • Melanie Grusdat
    • Dirk Brenner
    News & Views
  • A landmark study reveals how Kupffer cells, resident macrophages of the liver, can promote antitumor immunity. Central to this function is ID3, a Kupffer cell lineage-determining factor. The findings provide new insights into cancer therapy.

    • Anne-Gaëlle Goubet
    • Mikaël J. Pittet
    News & Views
  • The development of therapies for ischemic stroke requires a deep understanding of the immune response to injury. Analysis now defines immune cell origin, disease stage-specific responses, and the effects of age and sex after ischemic stroke.

    • Danye Jiang
    • Louise McCullough
    News & Views
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Research Briefings

  • Cancer cells often rely on glycolysis for energy metabolism. Increased glycolysis leads to the increased production of lactate and H+ ions, which should hypothetically lower intracellular pH. However, we find that tumor cells combat intracellular over-acidification by synthesizing carnosine, especially under hypoxic conditions, which allows them to control lysosome-dependent galectin-9 expression and evade T cell-mediated immune surveillance.

    Research Briefing
  • In this study, we developed an adenoviral-vectored vaccine that targets the spike protein of BA.5 Omicron SARS-CoV-2. When nasally delivered in mice and hamsters, the vaccine stimulated mucosal antibody production and CD8+ T cell responses, and demonstrated protection against several SARS-CoV-2 strains, including the antigenically distant Omicron XBB.1.5 strain. Immune cell depletion studies showed that cross-reactive memory CD8+ T cells contribute to the cross-protection that is conferred by nasal vaccines against respiratory infection with antigenically shifted SARS-CoV-2 Omicron strains.

    Research Briefing
  • Bacillus Calmette–Guérin (BCG) is the only available vaccine against tuberculosis. As well as being an effective vaccine against tuberculosis, BCG also provides off-target protection against various pathogens. Here, we report a mechanism for BCG-mediated cross-protection against influenza A virus (IAV), which requires a dialogue between the innate and adaptive immune memory systems.

    Research Briefing
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Review Articles

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Articles

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Amendments & Corrections

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