The biochemical events that mediate inside-out signaling to β1 and β2 integrin receptors after TCR ligation are poorly understood. Using a transgenic mouse model, investigators have implicated an unexpected candidate, Rap1, as a key mediator of inside-out signaling in activated T cells.
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Abraham, R. Antigen receptors rap to integrin receptors. Nat Immunol 3, 212–213 (2002). https://doi.org/10.1038/ni0302-212
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DOI: https://doi.org/10.1038/ni0302-212
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