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High-grade glioblastoma demonstrates exceedingly poor patient survival rates. In their Review, Lim and colleagues describe the immunological mechanisms involved in the control of glioblastoma and the outlook for immunotherapy.
Pierce and colleagues discuss the cellular consequences of BCR signaling and recent advances in the understanding of B cell signaling in context in vivo.
Underlying inflammatory bowel disease is a complex web of activated immune cells. In this Review, Neurath delineates the cells, pathways and signals that contribute to the pathology of inflammatory bowel disease and the potential for therapeutic intervention.
In this Review, Pearce and colleagues discuss the metabolic adaptation of immune cells to various tissues and how functional adaptation compared with maladaptation within the niche can affect tissue homeostasis.
In this Review, Chavakis and colleagues discuss the mechanisms that govern the adaptation of hematopoietic progenitor cells to inflammation and its effects on the pathogenesis of human disease.
In this Review, Natoli and Ostuni discuss the mechanisms of adaptation and memory in immunity, with the aim of providing basic concepts that rationalize the properties and molecular bases of these essential processes.
Comprehensive immunity requires that cells sense intracellular pathogens. In their Review, Shao and colleagues describe mechanisms for the recognition of intracellular lipopolysaccharide and its essential role in responses to Gram-negative bacteria.
The skin and intestine are unique environments at the front line of the immune system. Powrie and colleagues review the distinctive adaptations acquired by regulatory T cells at these barrier surfaces.
Malaria remains a disease of global importance, and a fully protective vaccine is elusive. In this Focus Review, Cockburn and Seder describe how insights into the biology of malaria biology may lead to the design of an effective vaccine.
Screaton and colleagues discuss the role of the adaptive immune response against flaviviruses in protection and pathogenesis, with emphasis on cross-reactive T cell and antibody responses.
Sok and Burton highlight recent developments in the discovery and application of antibodies able to neutralize diverse isolates of HIV, known as ‘broadly neutralizing antibodies’.
Song and Colonna provide an overview of the common microglial response to neurodegeneration and discuss insights from mouse models and the study of human disease-associated genes.
He and Wang review the immunological functions of RIP kinases in inflammatory responses to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.
The immunoproteasome and thymoproteasome are specialized proteasomes operating within the immune system. In this Review, Murata et al. recount the discovery of the immunoproteasome and thymoproteasome and delve into their function, context in evolution and relation to human disease.
Romagnani and colleagues discuss the specific recognition of viral antigens and peptides by NK cells and its implications for the composition of the NK cell repertoire and the selection of viral variants.
The thymus has a critical role in the establishment of appropriately educated and self-tolerant T cells. In their Focus Review, Cheng and Anderson discuss the most recent insights into how the thymus establishes self-tolerance.
Treg cells have a critical role in maintaining peripheral tolerance. In this Focus Review, Dominguez-Villar and Hafler describe how the instability and plasticity of Treg cells can contribute to the breakdown of tolerance and lead to autoimmune disease.
Autoimmune disease has been the subject of intense genetic study. In this Focus Review, Todd and colleagues describe recent advances and approaches in the genetic analysis of autoimmune disease.
