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IgE-FcεRI complex formation represents a critical step in the initiation of allergic responses. Conformational changes involving the Cε2 domain may underlie the persistent activation of FcεRI-bearing cells.
Biofilms offer cover for many pathogenic bacteria. A recent paper in Nature reveals that lactoferrin is an innate tool that inhibits biofilm formation.
The identity of the thymic epithelium precursor has been elusive.A marker is now shown to identify a population of cells that can give rise to a functional thymus.
Higher eukaryotes can mount antiviral immune responses induced by dsRNA. This process, called RNA interference, is sequence specific and can therefore be used to target gene expression.