Volume 3 Issue 11, November 2000

Volume 3 Issue 11

Zebrafish larvae swim in the direction of perceived motion. Baier and colleagues now demonstrate that zebrafish larvae respond not only to first-order cues (defined by luminance), but also to higherorder stimuli lacking first-order information. These results are surprising because the ability to detect second-order motion is often thought to require cortical processing, and fish have no cortex. See page 1128.


Letters to Editor

News and Views

  • News & Views |

    Neural development seems normal in mice lacking single TGF-βs, but blocking function of all TGF-βs is now shown to rescue neurons from programmed apoptosis, suggesting that TGF-βs might determine the timing of vulnerability to trophic factor deprivation in development.

    • Richard J. Miller
    •  & Clifton W. Ragsdale
  • News & Views |

    The interaction of two untranslated sequences in the mRNA for calcium/calmodulin-dependent protein kinase II could regulate its activity-dependent transport into dendrites.

    • David G. Wells
    •  & Justin R. Fallon
  • News & Views |

    Zhu and colleagues show that delivery of AMPA receptors to synapses early in development is activity dependent and that it shares some, but not all, features with LTP.

    • Reed C. Carroll
    •  & Robert C. Malenka
  • News & Views |

    Erickson and colleagues suggest that nearby neurons in the perirhinal cortex share similar object preferences, and that these groups may develop based on visual experience.

    • Earl K. Miller
  • News & Views |

    An imaging study shows that recognition associated with a specific time and setting (episodic memory) activates the hippocampus—whereas other forms of recognition do not.

    • Randy L. Buckner

Book Review

Brief Communications



  • Focus |

    Computational Approaches to Brain Function

    This supplement contains eight specially commissioned review articles, in which leading experts discuss the application of computational modeling to a range of problems in contemporary neuroscience; topics include dendritic processing, stabilization of neuronal firing rates, short term memory, sensorimotor transformations, object recognition, control of movement, cerebellar function and attention. In addition to the reviews, the supplement contains six History pieces, which highlight some of the most influential theoretical models of the previous half-century, and six Viewpoints, in which prominent theoretical and experimental neuroscientists offer their personal views on the proper role of modeling in neuroscience.