Neural development seems normal in mice lacking single TGF-βs, but blocking function of all TGF-βs is now shown to rescue neurons from programmed apoptosis, suggesting that TGF-βs might determine the timing of vulnerability to trophic factor deprivation in development.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Massague, J. & Chen, Y. G. Genes Dev. 14, 627–644 (2000).
Merino, R. et al. Development 126, 5515–5522 (1999).
Lee, K. J. & Jessell, T. M. Annu. Rev. Neurosci. 22, 261–294 (1999).
Graham, A., Francis-West, P., Brickell, P. & Lumsden, A. Nature 372, 684–686 (1994).
Sanford, L. P. et al. Development 124, 2659–2670 (1997).
Flanders, K. C. et al. Development 113, 183–191 (1991).
Krieglstein, K. et al. Nat. Neurosci. 3, 1085–1090 (2000).
Hamburger, V. & Levi-Montalcini, R. J. Exp. Zool. 111, 457–501 (1949).
Oppenheim, R. W. Annu. Rev. Neurosci. 14, 453–501 (1991).
Pettmann, B. & Henderson, C. E. Neuron 20, 633–647 (1998).
Hamburger, V. Am. J. Anat. 102, 365–409 (1958).
Krieglstein, K., Farkas, L. & Unsicker, K. J. Neurobiol. 37, 563–572 (1998).
Raoul, C., Pettmann, B. & Henderson, C. E. Curr. Opin. Neurobiol. 10, 111–117 (2000).
Li, M. et al. Science 288, 335–339 (2000).
Goldberg, J. L. & Barres, B. A. Annu. Rev. Neurosci. 23, 579–612 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Miller, R., Ragsdale, C. Transforming growth factor-β: death takes a holiday. Nat Neurosci 3, 1061–1062 (2000). https://doi.org/10.1038/80557
Issue Date:
DOI: https://doi.org/10.1038/80557
