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Neural development seems normal in mice lacking single TGF-βs, but blocking function of all TGF-βs is now shown to rescue neurons from programmed apoptosis, suggesting that TGF-βs might determine the timing of vulnerability to trophic factor deprivation in development.
Zhu and colleagues show that delivery of AMPA receptors to synapses early in development is activity dependent and that it shares some, but not all, features with LTP.
An imaging study shows that recognition associated with a specific time and setting (episodic memory) activates the hippocampus—whereas other forms of recognition do not.