Single-cell mRNA cytometry

Single-cell mRNA cytometry enables isolation of rare cells from whole blood based on target mRNA sequences.

Latest Research

  • Article |

    Calcium-ion batteries are potentially attractive alternatives to lithium-ion batteries, but remain largely unexplored because of low performance. A reversible calcium alloying/de-alloying reaction with the tin anode has now been coupled with the intercalation/de-intercalation of hexafluorophosphate in the graphite cathode to enable a calcium-ion battery that operates stably at room temperature.

    Low-cost battery technology is attractive in the fields of electric vehicles and grid-scale energy storage. Now, a room-temperature calcium-ion battery exhibiting an average working voltage of 4.45 V and 95% capacity retention after 350 cycles has been developed. The new battery configuration and working mechanism contribute to its electrochemical performance.

    • Meng Wang
    • , Chunlei Jiang
    • , Songquan Zhang
    • , Xiaohe Song
    • , Yongbing Tang
    •  & Hui-Ming Cheng
  • Article |

    I-motif DNA structures are thought to form in cytosine-rich regions of the genome and to have regulatory functions; however, in vivo evidence for the existence of such structures has so far remained elusive. Now an engineered antibody that is selective for i-motif structures has been developed and used to detect i-motifs in the nuclei of human cells.

    • Mahdi Zeraati
    • , David B. Langley
    • , Peter Schofield
    • , Aaron L. Moye
    • , Romain Rouet
    • , William E. Hughes
    • , Tracy M. Bryan
    • , Marcel E. Dinger
    •  & Daniel Christ
  • Article |

    Our understanding of reaction dynamics has developed as more accurate measurements of product state-resolved angular distributions have become available. Now, fast forward-scattering oscillations in the product angular distribution of the benchmark chemical reaction H + HD → H2 + D have been observed and are in excellent agreement with quantum-mechanical dynamics calculations.

    • Daofu Yuan
    • , Shengrui Yu
    • , Wentao Chen
    • , Jiwei Sang
    • , Chang Luo
    • , Tao Wang
    • , Xin Xu
    • , Piergiorgio Casavecchia
    • , Xingan Wang
    • , Zhigang Sun
    • , Dong H. Zhang
    •  & Xueming Yang
  • Article |

    The M-cluster in the active site of nitrogenase is derived from an 8Fe core assembled via coupling and rearrangement of two [Fe4S4] clusters concomitant with the insertion of an interstitial carbon and a ninth sulfur. Now, by combining synthetic [Fe4S4] clusters and assembly with a protein template, it has been shown that sulfite gives rise to the ninth sulfur that is inserted into the nitrogenase cofactor after the radical SAM-dependent carbide insertion and cofactor core rearrangement.

    • Kazuki Tanifuji
    • , Chi Chung Lee
    • , Nathaniel S. Sickerman
    • , Kazuyuki Tatsumi
    • , Yasuhiro Ohki
    • , Yilin Hu
    •  & Markus W. Ribbe
  • Article |

    Collision-induced spin–orbit transitions involve multiple interaction potentials and are by nature non-adiabatic, complicating both their experimental and theoretical study. Crossed-beam experiments and non-Born–Oppenheimer quantum calculations for inelastic collisions of carbon atoms with helium atoms, down to energies corresponding to temperatures below 10 K, have now been performed. Quantum-dynamical resonances predicted by theory were experimentally detected.

    • Astrid Bergeat
    • , Simon Chefdeville
    • , Michel Costes
    • , Sébastien B. Morales
    • , Christian Naulin
    • , Uzi Even
    • , Jacek Kłos
    •  & François Lique
  • Article |

    Scattering of molecules at low temperature that are prepared in single quantum states illuminates the mechanism of rotationally inelastic collisions and reveals the reorientation of partner molecules. By correlating each outgoing partial wave with the incoming waves, partial-wave analysis of the scattering angular distribution determines the dominant short- and long-range anisotropies of the interaction potential.

    • William E. Perreault
    • , Nandini Mukherjee
    •  & Richard N. Zare

News & Comment

  • News & Views |

    Proteins are attractive material building blocks, yet their intrinsic functionality has remained largely untapped. Now, a protein-based material that exhibits controllable self-assembling behaviour has been prepared in a one-pot synthesis by simultaneous use of recombinant expression and post-translational modification.

    • Alvaro Mata
  • Thesis |

    To appreciate women’s contribution to science, Michelle Francl suggests it’s time to stop talking about the most famous one.

    • Michelle Francl
  • News & Views |

    Ribosomes have now been shown to accept certain initiator tRNAs acylated with aromatic foldamer–dipeptides thereby enabling the translation of a peptide or protein with a short aromatic foldamer at the N-terminus. Some foldamer–peptide hybrids could be cyclized to generate macrocycles that present conformationally restricted peptide loops.

    • Alanna Schepartz
  • News & Views |

    Evolution of highly functionalized DNA could enable the discovery of artificial nucleic acid sequences with different properties to natural DNA. Now, an artificial translation system has been designed that can support the evolution of non-natural sequence-defined nucleic acid polymers carrying eight different functional groups on 32 codons.

    • John C. Chaput

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