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Iga et al. perform single-cell RNA sequencing and identify a distinct bone marrow endothelial cell subtype that contributes to the acquisition of bone strength and offers a distinct haematopoietic stem cell niche.
Qu et al. identify and characterize reciprocal crosstalk between small-cell lung cancer cells and astrocytes, which mimics neuron–astrocyte interactions during brain development and promotes brain metastasis.
Ader et al. find a grommet-like role for ESCRTs distinct from their nuclear envelope sealing function after spindle pole body extrusion. The grommet works with spindle pole body components that establish a diffusion barrier to maintain compartmentalization.
Kramer, Prakash et al. share genome-wide CRISPR screens for factors that alter the levels of two dual-genome-encoded Complex IV subunits, COX1 and COX4. They identify PREPL and NME6 as genes that connect mitochondrial metabolism to mtDNA expression.
Zhang et al. report curved adhesions, which are integrin-based adhesions formed in response to membrane curvatures that can be imposed by the overlying extracellular matrix fibre geometry.
Shapiro, Chang, et al. identify a conserved role for the iron-binding histone demethylase KDM3B in sensing iron levels and regulating mTORC1 through transcriptional repression of key mTORC1 pathway components.
Bernabé-Rubio et al. report that dedifferentiation of Gata6+ epidermal cells occurs during wound healing or mechanical expansion of the epidermis through a Myc-dependent process that resembles reversal of differentiation.
Venkei et al. show that Y-linked Su(Ste) piRNAs are produced via 5′-to-3′ phased-biogenesis initiated by maternally deposited 1360/Hoppel-derived piRNAs, leading to silencing of Ste in the male germline.
Irie, Lee et al. report a role for DMRT1 in human germline development and show that induction of DMRT1 in primordial germ cell-like cells triggers germline commitment, but suppresses pluripotency genes, thus promoting the onset of gametogenesis.
Collignon et al. report that Mettl3-mediated m6A RNA methylation promotes developmental pausing in embryonic stem cells and blastocysts by establishing transcriptional dormancy.
Grigorash et al. report that depletion of p16High cells promotes a totipotent-like state to improve somatic cell reprogramming efficiency through an S-adenosyl-l-methionine-dependent mechanism.
Dou, Xiao, Shen, Wang et al. show that RBFOX2 recognizes m6A on chromatin-associated RNAs and recruits RBM15, YTHDC1 and PRC2 to facilitate transcription suppression. Inhibition of the axis exerts anti-leukaemic effects.
Filipescu et al. report that macroH2A deficiency in cancer-associated fibroblasts leads to altered chromatin looping and elevated inflammatory gene expression, thereby affecting immune cell function and limiting the anti-tumour response in melanoma.
Romanauska and Köhler manipulate the levels of endogenously produced saturated acyl chains in yeast and show that nuclear envelope and nuclear pore complex function are uniquely sensitive to lipid acyl chain unsaturation.
Duplaquet, Li et al. identify and characterize KDM6A as an epigenetic regulator that impacts chromatin accessibility to modulate ASCL1-to-NEUROD1 subtype switching in small cell lung cancer.
Meng et al. show that the RNA polymerase II elongation factor ELL3 suppresses the 5′ untranslated region activities of a subset of young LINE-1 elements, which activate genes such as Akt3, and regulate ERK signalling and naïve pluripotency in mouse embryonic stem cells.
Nicastro, Brohée et al. find that the fatty acid synthesis intermediate malonyl-CoA inhibits mTORC1, showing mTORC1 senses the capacity of a cell to synthesise fatty acids and linking fatty acid generation with the overall biosynthetic output through mTORC1.
Wang et al. show that intestinal sphingosine-1-phosphate is transferred to oocytes and influences sphingolipid metabolism in the next generations. In the offspring, sphingosine-1-phosphate protects Caenorhabditis elegans neurons against axon fragility.
Yang, Gomez et al. show that the pioneer factor SOX9 regulates the switch from epidermal stem cell to hair follicle stem cell fate by binding and opening hair follicle enhancers, while recruiting epigenetic factors away from epidermal enhancers.