Reviews & Analysis

A consensus epitope prediction approach identifies the epitopes responsible for 95% of the murine T-cell response to vaccinia virus.

A new community resource for fission yeast offers genome-wide data on open reading frames (ORFs) and protein localization.

Proteins that could not be displayed on the surface of phage are now amenable to this powerful selection technology.

A method for amplifying DNA from single bacterial cells shows promise for complete genome sequencing.

A new approach to reducing the immunological side effects of gene therapy exploits microRNA to knock down transgene expression in immune cells.

Spermatogonial stem cells in adult testis may be more versatile than embryonic stem cells.

Unraveling how a soil-dwelling bacterium kills insects promises to deliver new biopesticides.

A method for altering the substrate specificity of LuxR proteins may facilitate the engineering of artificial communication systems among cells.

Two new studies help explain how small interfering RNAs can escape detection by cytoplasmic sensors of viral RNAs.

DNA replicator sequences may improve the efficiency and safety of gene therapy.

Genetic regulators of cancer are identified by combining data on global gene expression and DNA copy number.

Two in vivo real-time single molecule assays demonstrate that stochastic gene expression results in punctuated bursts of protein synthesis.

An electro-optical method permits high-throughput screening of ion channel inhibitors.

An integrative approach highlights the challenge of identifying new antibiotic drug targets.