Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RNA interference below the immune radar

Two new studies help explain how small interfering RNAs can escape detection by cytoplasmic sensors of viral RNAs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Signaling pathways leading to induction of pro-inflammatory cytokines and type I interferon by siRNAs.

Bob Crimi

References

  1. Elbashir, S.M. et al. Nature 411, 494–498 (2001).

    Article  CAS  Google Scholar 

  2. Sioud, M. Trends Mol. Med. doi:10.1016/j.molmed.2006.02.004

  3. Marques, J.T. et al. Nat. Biotechnol. 24, 559–565 (2006).

    Article  CAS  Google Scholar 

  4. Yoneyama, M. et al. Nat. Immunol. 5, 730–737 (2004).

    Article  CAS  Google Scholar 

  5. Robbins, M.A. et al. Nat. Biotechnol. 24, 566–571 (2006).

    Article  CAS  Google Scholar 

  6. Kawai, T. & Akira, S. Nat. Immunol. 7, 131–137 (2006).

    Article  CAS  Google Scholar 

  7. Kim, D.-H. et al. Nat. Biotechnol. 23, 222–226 (2005).

    Article  CAS  Google Scholar 

  8. Bartel, D.P. Cell 116, 281–97 (2004).

    Article  CAS  Google Scholar 

  9. Sioud, M. J. Mol. Biol. 348, 1079–1090 (2005)

    Article  CAS  Google Scholar 

  10. Judge, A.D. et al. Nat. Biotechnol. 23, 457–462 (2005).

    Article  CAS  Google Scholar 

  11. Kariko, K. et al. Immunity 23, 165–175 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sioud, M. RNA interference below the immune radar. Nat Biotechnol 24, 521–522 (2006). https://doi.org/10.1038/nbt0506-521

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0506-521

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing