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Putting immunoinformatics to the test

A consensus epitope prediction approach identifies the epitopes responsible for 95% of the murine T-cell response to vaccinia virus.

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Figure 1: The traditional approach to epitope mapping the vaccinia genome would involve synthesizing almost 176,000 overlapping 8-mer, 9-mer and 10-mer peptides (gray).

Bob Crimi

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Moise, L., De Groot, A. Putting immunoinformatics to the test. Nat Biotechnol 24, 791–792 (2006). https://doi.org/10.1038/nbt0706-791

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