Nature Biotechnology

Algae-encoded biopharmaceuticals

Spirulina is used to manufacture a therapeutic antibody against campylobacter

Current issue

Knock-in on CRISPR’s door

Editorial 07 Jun 2022
Unconventional γδ T cells ‘the new black’ in cancer therapy

Elie Dolgin
News 15 Jun 2022
Caribou’s first CRISPR CAR-T impresses

News in Brief 15 Jun 2022
The clinical progress of mRNA vaccines and immunotherapies

Ann J. Barbier
Allen Yujie Jiang
Daniel G. Anderson
Review Article 09 May 2022
Cell types of origin of the cell-free transcriptome

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
Brief Communication Open Access 07 Feb 2022
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

Francisco J. Sánchez-Rivera
Bianca J. Diaz
Lukas E. Dow
Article 14 Feb 2022

Contents

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Nature Conference: RNA at the Bench and Bedside III

The third in a series of Nature Conferences highlighting the way RNA medicines continue to change the face of clinical practice. This conference explores progress in our understanding of the roles of RNAs in immune signaling and chronic disease associated with dysregulated inflammatory processes.
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Latest Research articles

Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage

Aneuploidy and chromosomal truncations are frequent outcomes of CRISPR–Cas9 editing in human T cells.

Alessio David Nahmad
Eli Reuveni
Adi Barzel
Article 30 Jun 2022
High-throughput total RNA sequencing in single cells using VASA-seq

VASA-seq sequences total RNA in single cells, revealing non-coding expression and splicing patterns.

Fredrik Salmen
Joachim De Jonghe
Alexander van Oudenaarden
Article Open Access 27 Jun 2022
A genome and gene catalog of glacier microbiomes

The bacterial life in glaciers is comprehensively catalogued and analyzed.

Yongqin Liu
Mukan Ji
Tandong Yao
Article 27 Jun 2022
Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

Cancer driver mutations are identified by predicting neutral mutation rates across the entire genome.

Maxwell A. Sherman
Adam U. Yaari
Bonnie Berger
Article Open Access 20 Jun 2022
Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds

Biosensors are developed from malleable hormone receptors.

Jesús Beltrán
Paul J. Steiner
Timothy A. Whitehead
Article Open Access 20 Jun 2022
A red light–responsive photoswitch for deep tissue optogenetics

A photoswitch based on a bacterial phytochrome enables optogenetic manipulations using red light.

Yuto Kuwasaki
Kazushi Suzuki
Moritoshi Sato
Article 13 Jun 2022

Latest Reviews & Analysis

- Profiling the total single-cell transciptome using droplet microfluidics
  
  Current high-throughput single-cell methods detect only a small part of the transcriptome. The workflow presented here integrates molecular analysis and droplet microfluidics to derive total transcriptomic atlases that encompass alternative splicing and non-coding transcripts in large numbers of single cells. The utility of this method is demonstrated by analysis of mouse gastrulation and early organogenesis.
  
  Research Briefing 28 Jun 2022
- Archiving the genomic and genetic resources of glaciers
  
  The Tibetan glacier genome and gene catalog includes 3,241 metagenome-assembled or cultured genomes spanning 30 phyla and over 25 million genes encoding non-redundant proteins. This catalog provides a wealth of resources for archiving glacier microbial diversity and bioprospecting for bioactive compounds, as well as a platform for global comparison of glacier microbiomes.
  
  Research Briefing 27 Jun 2022
- Plant hormone sensors as scaffolds for biosensor design
  
  Most plant hormone sensors, including the abscisic acid receptor PYR1, function through chemically induced dimerization. Using computationally designed libraries of PYR1, we created high-affinity receptors for 21 structurally diverse ligands, setting the stage for large-scale small-molecule biosensor development
  
  Research Briefing 20 Jun 2022
- Smartphone apps in the COVID-19 pandemic
  
  An overview of apps for outbreak epidemiology, individual screening and contact tracing during the COVID-19 pandemic.
  Jay A. Pandit
  Jennifer M. Radin
  Eric J. Topol
  
  Review Article 20 Jun 2022
- Measuring SARS-CoV-2 T cell immunity with a scalable qPCR-based assay
  
  We developed two quantitative PCR-based assays to detect SARS-CoV-2-specific T cell immunity: qTACT and dqTACT. The assays quantify CXCL10 mRNA, after incubation of whole blood with viral peptides, as a proxy of an antigen-specific T cell response, and will allow population-level monitoring of cellular immunity to SARS-CoV-2.
  
  Research Briefing 17 Jun 2022
- Towards the non-invasive imaging of brain networks and functions at high resolution
  
  Research Briefing 13 Jun 2022
- CRISPR comes a-knock-in to reprogram antibodies in vivo
  Harald Hartweger
  Michel C. Nussenzweig
  
  News & Views 09 Jun 2022
- Lipophilic siRNA conjugates yield durable silencing in extrahepatic tissues
  
  Research Briefing 08 Jun 2022
- Visualization of living cells and tissues in many colors
  
  Research Briefing 06 Jun 2022

News & Comment

PRO-ACTive sharing of clinical data

Neta Zach
Melanie L. Leitner
Correspondence 01 Jul 2022
Diagnostics to take your breath away

After decades of research and development, devices for detecting infectious agents in breath are finally maturing, with SARS-CoV-2 galvanizing progress. Carrie Arnold reports.

Carrie Arnold
News Feature 27 Jun 2022
Forum: Phillips-Cremins and Pombo

Podcast 15 Jun 2022
Biotech news from around the world

News in Brief 15 Jun 2022
AI’s plastic recycling

News in Brief 15 Jun 2022
CRISPR technology

Recent patents relating to CRISPR methods and compositions for gene editing and therapeutic use.

Patents 15 Jun 2022