The Iniquitate pipeline assessed the impacts of cell-type imbalance on single-cell RNA sequencing integration through perturbations to dataset balance. The results indicated that cell-type imbalance not only leads to loss of biological signal in the integrated space, but also can change the interpretation of downstream analyses after integration.
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References
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This is a summary of: Maan, H. et al. Characterizing the impacts of dataset imbalance on single-cell data integration. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02097-9 (2024).
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Imbalanced single-cell data integration leads to loss of biological information. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-02114-x
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DOI: https://doi.org/10.1038/s41587-023-02114-x
