The underrepresentation of functional glial cells is a major challenge in brain organoid models. We developed an astroglia-enriched cortical organoid model that allows efficient generation of functional astrocytes and enables the formation of astroglial morphological subclasses with layer-specific gene expression profiles upon transplantation into the mouse brain.
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References
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This is a summary of: Wang, M. et al. Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain. Nat. Biotechnol., https://doi.org/10.1038/s41587-024-02157-8 (2024).
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Glia-enriched cortical organoids implanted in mice capture astrocyte diversity. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02198-z
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DOI: https://doi.org/10.1038/s41587-024-02198-z
