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Zechner and colleagues discuss mechanisms facilitating the mobilization of intracellular fatty acids and how they affect lipid-mediated signalling, metabolic regulation and energy homeostasis in health and disease.
Wiley and Campisi discuss metabolic inducers of senescence and alterations in cellular metabolism associated with senescence, while pointing out interventions that target metabolic processes to mitigate senescence.
Adipose tissue has emerged as a highly heterogeneous organ. Sun et al. discuss the heterogeneity of thermogenic adipocytes and their precursors, highlighting the single-cell technologies that help to characterize adipose tissues in depth.
Schwartz et al. review mechanisms through which the central nervous system achieves metabolic homeostasis in the basal and postprandial states, and how dysfunction of this integrated central fuel homeostasis control system can contribute to metabolic disease.
Evers et al. explore the interconnection between cellular mechanics and metabolism, emerging paradigms and the role of this interaction in cancer, cardiovascular disease and fibrosis.
Cancer cells undergo metabolic rewiring to support unrestrained proliferation, but dependence on oncogenesis-supportive metabolites could be leveraged therapeutically. Geeraerts et al. explore the centrality of serine and glycine metabolism to cancer survival, and how targeting the de novo serine and glycine synthesis pathways can complement current therapies.
The tumour microenvironment (TME) is a unique cellular and metabolic landscape. Elia and Haigis describe how metabolism influences, and is affected by, the complexity of cellular interactions within the TME and highlight opportunities for therapeutic intervention.
Cellular metabolism has emerged as a major biological node governing cellular behaviour. In their review, Boon et al. explore the mechanisms that maintain nuclear metabolic compartmentalization and the regulation of epigenetics, cell fate and cell physiology by nuclear metabolism.
Franco et al, review how metabolic insufficiency and prolonged stress responses impact signaling cascades and epigenetic reprogramming to lock T cells into an exhausted state.
Exercise is a powerful modifier of organismal, tissue and cellular metabolism. In their Review, Koelwyn et al. highlight how exercise-induced alterations in the tumour microenvironment can affect immunometabolic mechanisms and how these changes may contribute to the benefits of exercise on cancer initiation and progression.
Kusuyama et al. review the effects of maternal and paternal exercise on offspring metabolic health in adulthood, the time of life when metabolic diseases typically surface.
Cellular metabolic demand skyrockets during intense exercise, thus rendering the communication of metabolic state essential for organismal homeostasis. Murphy, Watt and Febbraio discuss the physiological processes governing intertissue communication during exercise and the molecules mediating such cross-talk.
Hargreaves and Spriet review regulatory mechanisms of ATP resynthesis during exercise and summarize nutritional interventions that target muscle metabolism to enhance athletic performance.
Frampton et al. review emerging understanding of how the three primary gut-derived short-chain fatty acids—acetate, propionate and butyrate—affect skeletal muscle metabolism and function.
Childhood obesity is one of the most serious public-health challenges of this century. Here, Caprio et al. provide a Review encompassing several aspects of childhood obesity, including epidemiology, genetic and environmental contributions, and cardiometabolic complications.
Xu and colleagues provide a comprehensive overview of cholesterol metabolism in cancer cells and its effects on immune cells of the tumour microenvironment, highlighting its effects on cancer growth as well as opportunities for therapeutic intervention.
Pancreatic islets are heterogeneous clusters of endocrine cells responsible for glucose homeostasis. Here Noguchi and Huising review the main stimuli for each islet-cell type and their response, guided by insights from islet-cell transcriptomes.
Systemic homeostasis is finely orchestrated by the action of several organs and molecules. Here Priest et al. provide a comprehensive review that highlights the inter-organ communication complexity in metabolic regulation.
