Articles in 2024

A parameterized physical model that uses unpaired datasets for adaptive holographic imaging was published in Nature Machine Intelligence in 2023. Zhang and colleagues evaluate its performance and extend it to non-perfect optical systems by integrating specific optical response functions.

Machine learning algorithms play important roles in medical imaging analysis but can be affected by biases in training data. Jones and colleagues discuss how causal reasoning can be used to better understand and tackle algorithmic bias in medical imaging analysis.

Deep learning language models have proved useful for both natural language and protein modelling. Similar to semantics in natural language, protein functions are complex and depend on the context of their environment, rather than on the similarity of sequences. Kulmanov and colleagues present an approach to frame function prediction as semantic entailment using a neuro-symbolic model to augment a large protein language model.

The “My Seizure Gauge” competition explored the challenge of forecasting epileptic seizures using non-invasive wearable devices without an electroencephalogram. The organizers and the winning team reflect on their experiences.

Denoising low-counting statistics data in the presence of multiple, unknown noise profiles is a challenging task in scientific applications where high accuracy is required. Oppliger and colleagues train a deep convolutional neural network on pairs of experimental low- and high-noise X-ray diffraction data and demonstrate better performance on experimental noise filtering compared with the case of training on artificial data pairs.

Realistic quantum mechanical simulations are computationally costly to perform but can be approximated using neural network models. Li and colleagues propose a forward propagation method in lieu of traditional backpropagation to speed up these neural network-based approaches.

Great advances in protein structure prediction have been made with recent deep learning-based methods, but proteins interact with their environment and can change shape drastically when binding to ligand molecules. To predict the 3D structure of these combined protein–ligand complexes, Qiao et al. developed a generative diffusion model with biophysical constraints and geometric deep learning.

AI-enabled diagnostic applications in healthcare can be powerful, but study design is very important to avoid subtle issues of bias in the dataset and evaluation. Coppock et al. demonstrate how an AI-based classifier for diagnosing SARS-Cov-2 infection from audio recordings can seem to make predictions with high accuracy but shows much lower performance after taking into account confounders, providing insights in study design and replicability in AI-based audio analysis.

Recent work has demonstrated important parallels between human visual representations and those found in deep neural networks. A new study comparing functional MRI data to deep neural network models highlights factors that may determine this similarity.

Machine learning techniques are widely employed in chemical science, but are application specific and their development requires dedicated expertise. Jablonka and colleagues fine-tune the GPT-3 model and show that it can provide surprisingly accurate answers to a wide range of chemical questions.

We reflect on five years of Nature Machine Intelligence and on providing a venue for discussions in AI.

Machine learning is increasingly applied for disease diagnostics due to its ability to discover differentiating features in data. However, the clinical applicability of these models remains a challenge. Pavlović et al. provide an overview of the challenges in using machine learning for biomarker discovery and suggest a causal perspective as a solution.

For our fifth anniversary, we reconnected with authors of recent Comments and Perspectives in Nature Machine Intelligence and asked them how the topic they wrote about developed. We also wanted to know what other topics in AI they found exciting, surprising or worrying, and what their hopes and expectations are for AI in 2024—and the next five years. A recurring theme is the ongoing developments in large language models and generative AI, their transformative effect on the scientific process and concerns about ethical implications.

Recent years have seen many advances in deep learning models for protein design, usually involving a large amount of training data. Focusing on potential clinical impact, Garton et al. develop a variational autoencoder approach trained on sparse data of natural sequences of adenoviruses to generate large proteins that can be used as viral vectors in gene therapy.

Designing antibodies and assessing their biophysical properties for potential therapeutic development is challenging with current computational methods. Ramon et al. have developed a deep learning approach called AbNatiV, based on a vector-quantized variational encoder that accurately assesses the nativeness of antibodies and nanobodies, which are small single-domain antibodies that have recently attracted considerable interest.

Drug design has recently seen immense improvements in computational methods, but models can still struggle generalizing across binding pockets. Feng and colleagues combine a language model with geometric deep learning to provide efficient generation of potential new drugs.

Accurate real-time tracking of dexterous hand movements and interactions has applications in human–computer interaction, the metaverse, robotics and tele-health. Capturing realistic hand movements is challenging due to the large number of articulations and degrees of freedom. Tashakori and colleagues report accurate and dynamic tracking of articulated hand and finger movements using machine-learning powered stretchable, washable smart gloves.

Magnetic microrobots are of considerable interest for non-invasive biomedical applications but it is challenging to develop a general strategy for controlling microrobot positions, for varying configurations and environments. Choi et al. develop a reinforcement learning control method, training the model in a simulation environment for initial exploration after which the learning process is transferred to a physical electromagnetic actuation system.