Volume 101 Issue 1, January 2021

Volume 101 Issue 1

In this issue, the paper by Yamazaki et al describes how continuous formation of small clusters of LGR5-positive cells contribute to tumor growth in colorectal cancer. The cover shows distribution of LGR5-positive cells (green) and HLA-DMA (red) in 3D structures.

Inside the USCAP Journals

Mini Review

  • Mini Review |

    This mini-review summarizes the role of βcysteine 93 in oxidative stability of hemoglobin in human blood. βCys93 has been recognized as an end point for radicals originating from heme during oxidative stress and therefore it may be an important biological marker of oxidative stability of hemoglobin within red blood cells intended for transfusion or in hemoglobinopathies.

    • Abdu I. Alayash


Technical Report

  • Technical Report |

    This study shows in vivo and in vitro evidence to support a novel tree shrew model of lung fibrosis. Tree shrews are genetically, anatomically, and metabolically closer to humans than rodents or dogs; therefore, the tree shrew model presents a unique opportunity for basic and translational research in lung fibrosis.

    • Pulin Che
    • , Meimei Wang
    •  & Qiang Ding
  • Technical Report |

    Photoactivatable-Cre (PA-Cre) knock-in mice was established and characterized for the spatial regulation of Cre recombinase activity with blue light exposure. Spot irradiation or long-term irradiation using a wireless LED could induce locus-specific recombination. The PA-Cre knock-in mice promise a useful resource to elucidate gene function in vivo spatiotemporally.

    • Kazuto Yoshimi
    • , Yuko Yamauchi
    •  & Tomoji Mashimo



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